Wen-Ying Zhou , Xiao-Xiao Zheng , Yang-Mei Ou , Yang-Lin Ou , Hong-Yu Jang , Yu-Xin Peng , Yi-Yi Wang , Bi-Qing Zhao , Li Li
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引用次数: 0
Abstract
Sesquiterpenes are a class of natural products known for their diverse structures and biological activities. In this study, three new sesquiterpenes, crotiglimins A (1), B (2) and C (3) were isolated from the leaves of Croton tiglium collected in Yibin County of Sichuan Province, People’s Republic of China. The structures of all isolated compounds were determined on the basis of extensive spectroscopic analyses, as well as by comparison with literature reports. Compounds 1–3 were examined for their cytotoxic activities against the HepG2 cells, and IC50 values of 1, 2, and 3 are 20.67, 10.13, and 9.65 μM, respectively. Therefore, compounds 1–3 have the value of further research and may be serve as potential anti-liver cancer agent in the future.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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