Recent advances in Schiff bases and Cu(II) complexes: Applications in fluorescence imaging and anticancer therapy (2020–2024)

Abstract

Schiff base derivatives have garnered significant attention for their bioimaging and anticancer potentials. In the realm of bioimaging, Schiff base derivatives have shown exceptional capabilities in detecting various metal ions, due to their strong binding affinities and fluorescence properties. Moreover, the potential Schiff bases and their Cu(II) complexes as anticancer agents is being actively explored, with studies demonstrating their ability to induce apoptosis and inhibit cell proliferation in various cancer cell lines. This review article provides a comprehensive overview of recent advancements in the field of cell imaging utilizing Schiff base derivatives for the recognition of Cu²⁺ in living cells and organisms. From 2022 to 2024, significant progress has been made in understanding the applications of Schiff bases in cell imaging techniques, ranging from fluorescence microscopy to molecular imaging modalities. Additionally, article has focused on leveraging the unique properties of Schiff base Cu(II) complexes to expand the anticancer efficacy. The article offering insights into the mechanisms underlying enhanced anticancer activity and the development of novel anticancer agents.