Microbial cell factories for bioconversion of lignin to vanillin — Challenges and opportunities: A review

IF 8.5 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Biological Macromolecules Pub Date : 2025-04-03 DOI:10.1016/j.ijbiomac.2025.142805

Sultan Suboktagin , Muhammad Wajid Ullah , Sivasamy Sethupathy , Hareef Ahmed Keerio , Khulood Fahad Alabbosh , Khalid Ali Khan , Daochen Zhu

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Abstract

The bioconversion of lignin into vanillin via microbial cell factories offers a promising and sustainable route for producing high-value aromatic compounds from the abundant and underutilized byproducts of plant biomass. This review comprehensively explores the synthesis, structural characteristics, and diverse industrial applications of lignin, while addressing the inherent challenges posed by its complex structure in bioconversion processes. It examines the potential of microbial cell factories for lignin degradation, emphasizing the latest advancements in genetic engineering and metabolic optimization strategies that enhance microbial efficiency in lignin degradation and vanillin biosynthesis. It further assesses the economic feasibility of lignin-to-vanillin conversion by discussing key factors influencing cost-effectiveness and scalability, highlighting the transformative potential for producing high-value aromatic compounds in an environmentally sustainable manner. The review also highlights ongoing research efforts to develop robust microbial strains and optimize metabolic pathways for improved vanillin yield. By integrating multidisciplinary approaches, this review highlights the transformative potential of microbial cell factories to valorize lignin, offering a sustainable pathway for the production of vanillin and related aromatic compounds.

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木质素生物转化为香兰素的微生物细胞工厂——挑战与机遇：综述。

通过微生物细胞工厂将木质素转化为香兰素，为从大量未充分利用的植物生物质副产品中生产高价值芳香族化合物提供了一条有前途的可持续途径。本文综述了木质素的合成、结构特点及其在工业上的广泛应用，并对其复杂结构在生物转化过程中所面临的挑战进行了探讨。它探讨了微生物细胞工厂降解木质素的潜力，强调了基因工程和代谢优化策略的最新进展，提高了木质素降解和香兰素生物合成的微生物效率。通过讨论影响成本效益和可扩展性的关键因素，进一步评估了木质素转化为香兰素的经济可行性，强调了以环境可持续的方式生产高价值芳香族化合物的变革潜力。该综述还强调了正在进行的研究工作，以开发健壮的微生物菌株和优化代谢途径，以提高香兰素产量。通过整合多学科方法，本综述强调了微生物细胞工厂对木质素的转化潜力，为香兰素和相关芳香族化合物的生产提供了可持续的途径。

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来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.