Combination of the microalga Pavlova sp. OPMS 30543 with diclofenac attenuates hyperalgesia in adjuvant-induced arthritis mice.

IF 1.3 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-06-23 DOI:10.1093/bbb/zbaf047

Wataru Nemoto, Kotaro Yamada, Ruka Kobayashi, Tomohiro Hoshi, Ken Nakahara, Akihiko Kanamoto, Osamu Nakagawasai, Koichi Tan-No

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Abstract

Marine microalgae, such as Pavlova spp, are known to produce bioactive compounds and have been extensively studied as natural resources with anti-inflammatory properties. Among several Pavlova spp, OPMS 30543 (Pav) has recently been found to contain a high fucoxanthin content. In this study, we aimed to evaluate the effects of Pav treatment on hyperalgesia using a mouse model of adjuvant-induced arthritis (AIA), which was established by injecting complete Freund's adjuvant. Pav alone did not suppress the hyperalgesia observed in AIA mice. However, combined with low-dose diclofenac (DFC; 0.1 mg/kg) resulted in marked analgesia. In AIA mice, the activation of excitatory neurons was observed in the spinal cord; however, this activation was suppressed by the combination of Pav and DFC. These findings suggest that Pav enhances the analgesic effect of DFC in a mouse arthritis-associated hyperalgesia, and may aid in the development of improved strategies for inflammatory pain management.

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微藻Pavlova sp. OPMS 30543与双氯芬酸联合使用可减轻佐剂性关节炎小鼠的痛症过敏。

众所周知，海洋微藻（如Pavlova spp.）可以产生生物活性化合物，并作为具有抗炎特性的天然资源被广泛研究。在几种巴甫洛娃属植物中，最近发现OPMS 30543 （Pav）含有较高的岩藻黄质。在这项研究中，我们旨在通过注射完全弗氏佐剂（CFA）建立佐剂性关节炎（AIA）小鼠模型，评估Pav治疗对痛症过敏的影响。单独Pav不能抑制AIA小鼠的痛觉过敏。然而，与低剂量双氯芬酸(DFC；0.1 mg/kg)导致明显的镇痛效果。在AIA小鼠中，在脊髓中观察到兴奋性神经元的激活；然而，Pav和DFC的结合抑制了这种激活。这些研究结果表明，Pav增强了DFC在小鼠关节炎相关痛觉过敏中的镇痛作用，并可能有助于改善炎症性疼痛管理策略的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).