Long-term health-related quality of life in survivors of extracorporeal cardiopulmonary resuscitation compared to conventional cardiopulmonary resuscitation- A cohort study using Australian and New Zealand extracorporeal membrane oxygenation registry and the Victorian Ambulance Cardiac Arrest Registry

IF 4.6 1区医学 Q1 CRITICAL CARE MEDICINE Resuscitation Pub Date : 2025-05-01 Epub Date: 2025-04-03 DOI:10.1016/j.resuscitation.2025.110601

Vinodh Bhagyalakshmi Nanjayya , Bentley Fulcher , Emily Nehme , Ary Serpa Neto , Alistair Nichol , David M. Kaye , D. James Cooper , Ziad Nehme , Stephen Bernard , Vincent Pellegrino , Alisa M. Higgins , Carol L. Hodgson

{"title":"Long-term health-related quality of life in survivors of extracorporeal cardiopulmonary resuscitation compared to conventional cardiopulmonary resuscitation- A cohort study using Australian and New Zealand extracorporeal membrane oxygenation registry and the Victorian Ambulance Cardiac Arrest Registry","authors":"Vinodh Bhagyalakshmi Nanjayya , Bentley Fulcher , Emily Nehme , Ary Serpa Neto , Alistair Nichol , David M. Kaye , D. James Cooper , Ziad Nehme , Stephen Bernard , Vincent Pellegrino , Alisa M. Higgins , Carol L. Hodgson","doi":"10.1016/j.resuscitation.2025.110601","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><div>To compare the long-term health-related quality of life (HRQoL) between patients receiving extracorporeal cardiopulmonary resuscitation (ECPR) and conventional cardiopulmonary resuscitation (CCPR) for out-of-hospital cardiac arrest (OHCA).</div></div><div><h3>Methods and Settings</h3><div>A retrospective cohort study using the Australian and New Zealand extracorporeal membrane oxygenation (EXCEL) registry for ECPR cases and the Victorian Ambulance Cardiac Arrest Registry (VACAR) for CCPR cases. All the adult patients with OHCA who had their cardiac arrest and 12-month HRQoL data recorded between July 2019 and July 2023 were eligible for inclusion. The primary outcomes were the 12-month EuroQol five-dimension (EQ-5D-5L) utility score and EuroQol visual analogue score (EQ-VAS).</div></div><div><h3>Results</h3><div>There were 33/122(28%) ECPR and 1,074/8,990(12%) CCPR OHCA survivors at 12 months. Of these, 24 (73%) ECPR and 754 (70%) CCPR survivors had HRQoL data. The ECPR cohort was younger [mean(SD) 50.4(13.46) vs 60.5(14.01) yrs, <em>p</em> < 0.01] and more likely to have received bystander CPR [19(79%) ECPR vs 397(52%) CCPR, <em>p</em> < 0.001]. Both cohorts had similar proportions of males, witnessed arrests and initial shockable rhythms. Median (IQR) arrest to ROSC/ECMO time was longer in ECPR than CCPR [61(41.5–97) vs 6(2–14) minutes, <em>p</em> < 0.001]. The median (IQR) EQ-5D-5L utility score [0.95 (0.72–1) ECPR vs 0.96 (0.86–1) CCPR, <em>p</em> = 0.64] and median (IQR) EQ-VAS at 12 months [80 (64.5–90) ECPR vs 75 (60–85) CCPR, <em>p</em> = 0.39] were similar. There were no significant differences in the EQ-5D-5L utility scores and EQ-VAS even after adjustment for baseline imbalances.</div></div><div><h3>Conclusions</h3><div>Despite significant baseline differences between ECPR and CCPR, there were no differences in HRQoL at 12 months.</div></div>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"210 ","pages":"Article 110601"},"PeriodicalIF":4.6000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Resuscitation","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0300957225001133","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/3 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CRITICAL CARE MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Aim

To compare the long-term health-related quality of life (HRQoL) between patients receiving extracorporeal cardiopulmonary resuscitation (ECPR) and conventional cardiopulmonary resuscitation (CCPR) for out-of-hospital cardiac arrest (OHCA).

Methods and Settings

A retrospective cohort study using the Australian and New Zealand extracorporeal membrane oxygenation (EXCEL) registry for ECPR cases and the Victorian Ambulance Cardiac Arrest Registry (VACAR) for CCPR cases. All the adult patients with OHCA who had their cardiac arrest and 12-month HRQoL data recorded between July 2019 and July 2023 were eligible for inclusion. The primary outcomes were the 12-month EuroQol five-dimension (EQ-5D-5L) utility score and EuroQol visual analogue score (EQ-VAS).

Results

There were 33/122(28%) ECPR and 1,074/8,990(12%) CCPR OHCA survivors at 12 months. Of these, 24 (73%) ECPR and 754 (70%) CCPR survivors had HRQoL data. The ECPR cohort was younger [mean(SD) 50.4(13.46) vs 60.5(14.01) yrs, p < 0.01] and more likely to have received bystander CPR [19(79%) ECPR vs 397(52%) CCPR, p < 0.001]. Both cohorts had similar proportions of males, witnessed arrests and initial shockable rhythms. Median (IQR) arrest to ROSC/ECMO time was longer in ECPR than CCPR [61(41.5–97) vs 6(2–14) minutes, p < 0.001]. The median (IQR) EQ-5D-5L utility score [0.95 (0.72–1) ECPR vs 0.96 (0.86–1) CCPR, p = 0.64] and median (IQR) EQ-VAS at 12 months [80 (64.5–90) ECPR vs 75 (60–85) CCPR, p = 0.39] were similar. There were no significant differences in the EQ-5D-5L utility scores and EQ-VAS even after adjustment for baseline imbalances.

Conclusions

Despite significant baseline differences between ECPR and CCPR, there were no differences in HRQoL at 12 months.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

体外心肺复苏幸存者与传统心肺复苏相比的长期健康相关生活质量——一项使用澳大利亚和新西兰体外膜氧合登记和维多利亚救护车心脏骤停登记的队列研究。

目的：比较院外心脏骤停（OHCA）患者接受体外心肺复苏（ECPR）与常规心肺复苏（CCPR）的长期健康相关生活质量（HRQoL）。方法和设置：一项回顾性队列研究，使用澳大利亚和新西兰体外膜氧合（EXCEL）登记ECPR病例和维多利亚州救护车心脏骤停登记（VACAR）登记CCPR病例。所有在2019年7月至2023年7月期间记录心脏骤停和12个月HRQoL数据的成年OHCA患者均符合纳入条件。主要结果为12个月EuroQol五维（EQ-5D-5L）效用评分和EuroQol视觉模拟评分（EQ-VAS）。结果：12个月时ECPR存活33/122例（28%），CCPR存活1,074/8,990例（12%）。其中24例（73%）ECPR幸存者和754例（70%）CCPR幸存者有HRQoL数据。ECPR队列更年轻[平均（SD） 50.4(13.46) vs 60.5（14.01）岁]。结论：尽管ECPR和CCPR的基线有显著差异，但12个月时的HRQoL没有差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Resuscitation 医学-急救医学

CiteScore

12.00

自引率

18.50%

发文量

556

审稿时长

21 days

期刊介绍： Resuscitation is a monthly international and interdisciplinary medical journal. The papers published deal with the aetiology, pathophysiology and prevention of cardiac arrest, resuscitation training, clinical resuscitation, and experimental resuscitation research, although papers relating to animal studies will be published only if they are of exceptional interest and related directly to clinical cardiopulmonary resuscitation. Papers relating to trauma are published occasionally but the majority of these concern traumatic cardiac arrest.