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Prehospital antiplatelet therapy in OHCA-Why before PCI?
IF 6.5 1区 医学 Q1 CRITICAL CARE MEDICINE Pub Date : 2025-04-21 DOI: 10.1016/j.resuscitation.2025.110613
Marko Noc, Misa Fister
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引用次数: 0
Race is not associated with medical emergency team evaluation prior to in-hospital cardiac arrest
IF 6.5 1区 医学 Q1 CRITICAL CARE MEDICINE Pub Date : 2025-04-16 DOI: 10.1016/j.resuscitation.2025.110609
Cody-Aaron L. Gathers , Ryan W. Morgan , Jessica S. Alvey , Ron Reeder , Zachary D. Goldberger , Jessica Fowler , Maryam Y. Naim , Amanda O’Halloran , Raina M. Merchant , Martha Kienzle , Vinay Nadkarni , Robert A. Berg , Robert M. Sutton , American Heart Association’s Get With The Guidelines®-Resuscitation Investigators

Background

Black patients have worse outcomes after in-hospital cardiac arrest (IHCA). Whether these racial disparities are associated with medical emergency team (MET) evaluation prior to IHCA remains unknown.

Methods

A retrospective cohort study of adults age ≥ 18 years from the American Heart Association Get With The Guidelines® Resuscitation registry who had an IHCA between 2000 and 2021 with acute physiologic decline (modified early warning score [MEWS] ≥ 3) during the 24 h prior to IHCA. A propensity-weighted cohort was constructed to balance confounders between Black and White patients. The association between race and MET evaluation was quantified with weighted multivariable logistic regression.

Results

Among 354,480 patients, 88,507 met the initial inclusion criteria, of which 29,714 patients (median age 69 [IQR 58–79] years, 42.5% female, and 26.9% Black) had acute physiologic decline during the 24 h prior to IHCA. Among patients with acute physiologic decline, 4102 (13.8%) patients had a preceding MET evaluation before IHCA. Rates of MET evaluation prior to cardiac arrest did not differ significantly between Black and White patients with acute physiologic decline (aOR 1.02, 95% CI 0.94–1.11, p = 0.62).

Conclusions

Though racial disparities in IHCA outcomes exist, this study did not detect a difference in rates of MET evaluation prior to IHCA among patients with acute physiologic decline as a potential mechanism for these disparities.
{"title":"Race is not associated with medical emergency team evaluation prior to in-hospital cardiac arrest","authors":"Cody-Aaron L. Gathers ,&nbsp;Ryan W. Morgan ,&nbsp;Jessica S. Alvey ,&nbsp;Ron Reeder ,&nbsp;Zachary D. Goldberger ,&nbsp;Jessica Fowler ,&nbsp;Maryam Y. Naim ,&nbsp;Amanda O’Halloran ,&nbsp;Raina M. Merchant ,&nbsp;Martha Kienzle ,&nbsp;Vinay Nadkarni ,&nbsp;Robert A. Berg ,&nbsp;Robert M. Sutton ,&nbsp;American Heart Association’s Get With The Guidelines®-Resuscitation Investigators","doi":"10.1016/j.resuscitation.2025.110609","DOIUrl":"10.1016/j.resuscitation.2025.110609","url":null,"abstract":"<div><h3>Background</h3><div>Black patients have worse outcomes after in-hospital cardiac arrest (IHCA). Whether these racial disparities are associated with medical emergency team (MET) evaluation prior to IHCA remains unknown.</div></div><div><h3>Methods</h3><div>A retrospective cohort study of adults age ≥ 18 years from the American Heart Association Get With The Guidelines® Resuscitation registry who had an IHCA between 2000 and 2021 with acute physiologic decline (modified early warning score [MEWS] ≥ 3) during the 24 h prior to IHCA. A propensity-weighted cohort was constructed to balance confounders between Black and White patients. The association between race and MET evaluation was quantified with weighted multivariable logistic regression.</div></div><div><h3>Results</h3><div>Among 354,480 patients, 88,507 met the initial inclusion criteria, of which 29,714 patients (median age 69 [IQR 58–79] years, 42.5% female, and 26.9% Black) had acute physiologic decline during the 24 h prior to IHCA. Among patients with acute physiologic decline, 4102 (13.8%) patients had a preceding MET evaluation before IHCA. Rates of MET evaluation prior to cardiac arrest did not differ significantly between Black and White patients with acute physiologic decline (aOR 1.02, 95% CI 0.94–1.11, <em>p</em> = 0.62).</div></div><div><h3>Conclusions</h3><div>Though racial disparities in IHCA outcomes exist, this study did not detect a difference in rates of MET evaluation prior to IHCA among patients with acute physiologic decline as a potential mechanism for these disparities.</div></div>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"211 ","pages":"Article 110609"},"PeriodicalIF":6.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sociodemographic disparities in incidence and survival for pediatric out-of-hospital cardiac arrest in the United States
IF 6.5 1区 医学 Q1 CRITICAL CARE MEDICINE Pub Date : 2025-04-15 DOI: 10.1016/j.resuscitation.2025.110607
Cody-Aaron L. Gathers , Joseph W. Rossano , Heather Griffis , Bryan McNally , Rabab Al-Araji , Robert A. Berg , Sarita Chung , Vinay Nadkarni , Joshua M. Tobin , Maryam Y. Naim

Background

Sociodemographic disparities in pediatric out-of-hospital cardiac arrest (OHCA) outcomes exist; differences in pediatric OHCA incidence remain unknown. This study investigated the association between race, ethnicity, and socioeconomic status (SES) with pediatric OHCA incidence and survival. We hypothesized that children who are Black, Hispanic/Latino, or of lower SES would have higher incidence and lower survival rates compared to children who are White or of higher SES.

Methods

This is a retrospective cohort study (2015–2019) of the Cardiac Arrest Registry to Enhance Survival database. We included OHCAs among children < 18 years. The exposures were race, ethnicity, or SES index score. The SES index score incorporated race or ethnicity, household income, high school graduation rates, and unemployment rates on a scale from 0 to 4, with 4 indicating the highest-risk neighborhoods. The primary outcome was incidence (measured per 100,000 children of a particular group). Secondary outcomes included survival to hospital discharge and survival with a favorable neurologic outcome.

Results

Among 6945 OHCAs, 2320 (33.4%) occurred in Black children, 739 (10.6%) in Hispanic/Latino children, 2161 (31.1%) in White children, 188 (2.7%) in children of Other race, and 2855 (41.2%) in highest-risk neighborhoods. Black children had the highest OHCA incidence (15.5) as compared to Hispanic/Latino children (3.3) and White children (3.8), p < 0.001. OHCA incidence was higher in highest-risk neighborhoods (11.6) compared to lowest-risk neighborhoods (4.3), p < 0.001. Black children had lower odds of survival to hospital discharge (adjusted odds ratio [aOR] 0.73, 95% CI 0.59–0.91) and neurologically favorable survival (aOR 0.64, 95% CI 0.50–0.82) compared to White children. Hispanic/Latino children did not have significantly worse survival outcomes compared to White children. Children from the highest-risk neighborhoods had lower odds of survival to hospital discharge (aOR 0.64, 95% CI 0.50–0.81) and neurologically favorable survival (aOR 0.54, 95% CI 0.41–0.71) compared to children from the lowest-risk neighborhoods.

Conclusions

Black children have over four times the OHCA incidence compared to White and Hispanic/Latino children. Children from the highest-risk neighborhoods have more than twice the OHCA incidence compared to children from the lowest-risk neighborhoods. Black children and children from the highest-risk neighborhoods have significantly lower OHCA survival rates.
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引用次数: 0
AI-enhanced resuscitation image production training: advancing diversity and inclusion with GPT-4o
IF 6.5 1区 医学 Q1 CRITICAL CARE MEDICINE Pub Date : 2025-04-09 DOI: 10.1016/j.resuscitation.2025.110603
Johannes Wittig, Jacqueline Eleonora Ek, Federico Semeraro, Jonathan Montomoli, Elena Giovanna Bignami
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引用次数: 0
Outcomes after extracorporeal cardiopulmonary resuscitation in pediatric in-hospital cardiac arrest: does quality of CPR matter?
IF 6.5 1区 医学 Q1 CRITICAL CARE MEDICINE Pub Date : 2025-04-07 DOI: 10.1016/j.resuscitation.2025.110599
Tia T. Raymond , Priscilla Yu , Ivie Esangbedo , Todd Sweberg , Javier J. Lasa , Xuemei Zhang , Heather Griffis , Vinay Nadkarni , pediRES-Q investigators

Background

ECPR patients who receive guideline-compliant CPR will have improved survival to hospital discharge (SHD) compared to patients who do not receive guideline-compliant CPR, regardless of CPR duration.

Methods

Retrospective, observational study from PediRES-Q of IHCA in children (<18 years) requiring ECMO to achieve ROSC. We assessed compliance of 60-sec chest compression (CC) epochs according to 2020 AHA guideline targets. Guideline-compliant CPR defined as > 60% epochs meeting compliance criteria for each target. Differences assessed utilizing Fisher’s exact tests. Logistic regression used to assess guideline compliance and SHD, controlling for age, arterial line, duration of CPR, and clustering by site.

Results

We analyzed 157 index ECPR events (> 5 epochs): 62 infants (<1 year), 52 children (1-<8 years), and 43 adolescents (8-≤18 years) with CPR quality metric data from 20 sites. Median CPR duration 54 mins (IQR 40,66), median weight 12.0 kgs (IQR 6.0,28.5), and 74/157 (47%) with a cardiac diagnosis. Guideline compliance was not significantly associated with SHD after adjusted logistic regression; however, overall compliance was poor across age groups: 0% in < 1 year, 4% in 1-<8 years and 10% in 8–18 years. Age and duration of CPR were significantly associated with SHD, as 8-<18 years had 64% lower odds of SHD than < 8 year (aOR = 0.36 {0.17, 0.76; P = 0.007) and every minute increase in duration of CPR decreased survival odds by 2% (aOR = 0.98 {0.96,1.0; P = 0.02).

Conclusion

While adherence to AHA guideline-complaint CPR was not significantly associated with SHD, patient age and CPR duration were significant predictors. These findings emphasize the need to better understand factors associated with survival after pediatric ECPR while also helping to drive improvements in ECPR care models.
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引用次数: 0
Eyeing a novel biomarker of post-arrest brain function 关注被捕后大脑功能的新型生物标记。
IF 6.5 1区 医学 Q1 CRITICAL CARE MEDICINE Pub Date : 2025-04-04 DOI: 10.1016/j.resuscitation.2025.110600
Laura Faiver, Jonathan Elmer
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引用次数: 0
The development and accuracy assessment of a wearable cardiopulmonary resuscitation real-time audio-visual feedback device 可穿戴式心肺复苏实时视听反馈设备的开发和准确性评估。
IF 6.5 1区 医学 Q1 CRITICAL CARE MEDICINE Pub Date : 2025-04-04 DOI: 10.1016/j.resuscitation.2025.110602
Wenwen Ma , Enze Liu , Landan Xiao , Yuanwen Song , Liangyuan Zhou , Chen Zhang , Huisheng Deng
To enhance the quality of chest compressions and survival rates from cardiac arrest, several real-time audio-visual feedback devices have been developed. However, many of these feedback devices have certain issues regarding their usage or effectiveness. In this paper, we report on a wearable cardiopulmonary resuscitation real-time audio − visual feedback device, which is crafted with liquid silicone material for the casing to minimize skin injury. The device can display compression data (depth and frequency) in real-time and provides feedback through three forms of prompts. It has been evaluated for the accuracy of depth and frequency measurements against a reference device. The experimental results indicate that this wearable feedback device can provide more accurate depth and frequency data, holding the potential to become a tool for safely and effectively guiding high-quality cardiopulmonary resuscitation.
{"title":"The development and accuracy assessment of a wearable cardiopulmonary resuscitation real-time audio-visual feedback device","authors":"Wenwen Ma ,&nbsp;Enze Liu ,&nbsp;Landan Xiao ,&nbsp;Yuanwen Song ,&nbsp;Liangyuan Zhou ,&nbsp;Chen Zhang ,&nbsp;Huisheng Deng","doi":"10.1016/j.resuscitation.2025.110602","DOIUrl":"10.1016/j.resuscitation.2025.110602","url":null,"abstract":"<div><div>To enhance the quality of chest compressions and survival rates from cardiac arrest, several real-time audio-visual feedback devices have been developed. However, many of these feedback devices have certain issues regarding their usage or effectiveness. In this paper, we report on a wearable cardiopulmonary resuscitation real-time audio − visual feedback device, which is crafted with liquid silicone material for the casing to minimize skin injury. The device can display compression data (depth and frequency) in real-time and provides feedback through three forms of prompts. It has been evaluated for the accuracy of depth and frequency measurements against a reference device. The experimental results indicate that this wearable feedback device can provide more accurate depth and frequency data, holding the potential to become a tool for safely and effectively guiding high-quality cardiopulmonary resuscitation.</div></div>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"211 ","pages":"Article 110602"},"PeriodicalIF":6.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term health-related quality of life in survivors of extracorporeal cardiopulmonary resuscitation compared to conventional cardiopulmonary resuscitation- A cohort study using Australian and New Zealand extracorporeal membrane oxygenation registry and the Victorian Ambulance Cardiac Arrest Registry
IF 6.5 1区 医学 Q1 CRITICAL CARE MEDICINE Pub Date : 2025-04-03 DOI: 10.1016/j.resuscitation.2025.110601
Vinodh Bhagyalakshmi Nanjayya , Bentley Fulcher , Emily Nehme , Ary Serpa Neto , Alistair Nichol , David M. Kaye , D. James Cooper , Ziad Nehme , Stephen Bernard , Vincent Pellegrino , Alisa M. Higgins , Carol L. Hodgson

Aim

To compare the long-term health-related quality of life (HRQoL) between patients receiving extracorporeal cardiopulmonary resuscitation (ECPR) and conventional cardiopulmonary resuscitation (CCPR) for out-of-hospital cardiac arrest (OHCA).

Methods and Settings

A retrospective cohort study using the Australian and New Zealand extracorporeal membrane oxygenation (EXCEL) registry for ECPR cases and the Victorian Ambulance Cardiac Arrest Registry (VACAR) for CCPR cases. All the adult patients with OHCA who had their cardiac arrest and 12-month HRQoL data recorded between July 2019 and July 2023 were eligible for inclusion. The primary outcomes were the 12-month EuroQol five-dimension (EQ-5D-5L) utility score and EuroQol visual analogue score (EQ-VAS).

Results

There were 33/122(28%) ECPR and 1,074/8,990(12%) CCPR OHCA survivors at 12 months. Of these, 24 (73%) ECPR and 754 (70%) CCPR survivors had HRQoL data. The ECPR cohort was younger [mean(SD) 50.4(13.46) vs 60.5(14.01) yrs, p < 0.01] and more likely to have received bystander CPR [19(79%) ECPR vs 397(52%) CCPR, p < 0.001]. Both cohorts had similar proportions of males, witnessed arrests and initial shockable rhythms. Median (IQR) arrest to ROSC/ECMO time was longer in ECPR than CCPR [61(41.5–97) vs 6(2–14) minutes, p < 0.001]. The median (IQR) EQ-5D-5L utility score [0.95 (0.72–1) ECPR vs 0.96 (0.86–1) CCPR, p = 0.64] and median (IQR) EQ-VAS at 12 months [80 (64.5–90) ECPR vs 75 (60–85) CCPR, p = 0.39] were similar. There were no significant differences in the EQ-5D-5L utility scores and EQ-VAS even after adjustment for baseline imbalances.

Conclusions

Despite significant baseline differences between ECPR and CCPR, there were no differences in HRQoL at 12 months.
{"title":"Long-term health-related quality of life in survivors of extracorporeal cardiopulmonary resuscitation compared to conventional cardiopulmonary resuscitation- A cohort study using Australian and New Zealand extracorporeal membrane oxygenation registry and the Victorian Ambulance Cardiac Arrest Registry","authors":"Vinodh Bhagyalakshmi Nanjayya ,&nbsp;Bentley Fulcher ,&nbsp;Emily Nehme ,&nbsp;Ary Serpa Neto ,&nbsp;Alistair Nichol ,&nbsp;David M. Kaye ,&nbsp;D. James Cooper ,&nbsp;Ziad Nehme ,&nbsp;Stephen Bernard ,&nbsp;Vincent Pellegrino ,&nbsp;Alisa M. Higgins ,&nbsp;Carol L. Hodgson","doi":"10.1016/j.resuscitation.2025.110601","DOIUrl":"10.1016/j.resuscitation.2025.110601","url":null,"abstract":"<div><h3>Aim</h3><div>To compare the long-term health-related quality of life (HRQoL) between patients receiving extracorporeal cardiopulmonary resuscitation (ECPR) and conventional cardiopulmonary resuscitation (CCPR) for out-of-hospital cardiac arrest (OHCA).</div></div><div><h3>Methods and Settings</h3><div>A retrospective cohort study using the Australian and New Zealand extracorporeal membrane oxygenation (EXCEL) registry for ECPR cases and the Victorian Ambulance Cardiac Arrest Registry (VACAR) for CCPR cases. All the adult patients with OHCA who had their cardiac arrest and 12-month HRQoL data recorded between July 2019 and July 2023 were eligible for inclusion. The primary outcomes were the 12-month EuroQol five-dimension (EQ-5D-5L) utility score and EuroQol visual analogue score (EQ-VAS).</div></div><div><h3>Results</h3><div>There were 33/122(28%) ECPR and 1,074/8,990(12%) CCPR OHCA survivors at 12 months. Of these, 24 (73%) ECPR and 754 (70%) CCPR survivors had HRQoL data. The ECPR cohort was younger [mean(SD) 50.4(13.46) vs 60.5(14.01) yrs, <em>p</em> &lt; 0.01] and more likely to have received bystander CPR [19(79%) ECPR vs 397(52%) CCPR, <em>p</em> &lt; 0.001]. Both cohorts had similar proportions of males, witnessed arrests and initial shockable rhythms. Median (IQR) arrest to ROSC/ECMO time was longer in ECPR than CCPR [61(41.5–97) vs 6(2–14) minutes, <em>p</em> &lt; 0.001]. The median (IQR) EQ-5D-5L utility score [0.95 (0.72–1) ECPR vs 0.96 (0.86–1) CCPR, <em>p</em> = 0.64] and median (IQR) EQ-VAS at 12 months [80 (64.5–90) ECPR vs 75 (60–85) CCPR, <em>p</em> = 0.39] were similar. There were no significant differences in the EQ-5D-5L utility scores and EQ-VAS even after adjustment for baseline imbalances.</div></div><div><h3>Conclusions</h3><div>Despite significant baseline differences between ECPR and CCPR, there were no differences in HRQoL at 12 months.</div></div>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"210 ","pages":"Article 110601"},"PeriodicalIF":6.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nature vs culture. Possible evolutionary basis for prevalent attention to airway obstruction in cardiac arrest witnesses
IF 6.5 1区 医学 Q1 CRITICAL CARE MEDICINE Pub Date : 2025-04-02 DOI: 10.1016/j.resuscitation.2025.110598
Andrea Scapigliati
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引用次数: 0
Cardiac arrest survivors’ self-reported cognitive function, and its association with self-reported health status, psychological distress, and life satisfaction—a Swedish nationwide registry study
IF 6.5 1区 医学 Q1 CRITICAL CARE MEDICINE Pub Date : 2025-04-01 DOI: 10.1016/j.resuscitation.2025.110550
Karin Larsson , Carina Hjelm , Anna Strömberg , Johan Israelsson , Anders Bremer , Jens Agerström , Nina Carlsson , Dionysia Tsoukala , Erik Blennow Nordström , Kristofer Årestedt

Aim

Self-reported cognitive function has been described as an important complement to performance-based measurements but has seldom been investigated in cardiac arrest (CA) survivors. Therefore, the aim was to describe self-reported cognitive function and its association with health status, psychological distress, and life satisfaction.

Methods

This study utilised data from the Swedish Register of Cardiopulmonary Resuscitation (2018–2021), registered 3–6 months post-CA. Cognitive function was assessed by a single question: “How do you experience your memory, concentration, and/or planning abilities today compared to before the cardiac arrest?”. Health status was measured using the EQ VAS, psychological distress with the Hospital Anxiety and Depression Scale, and overall life satisfaction with the Life Satisfaction checklist. Data were analysed using binary logistic regression.

Results

Among 4026 identified survivors, 1254 fulfilled the inclusion criteria. The mean age was 65.9 years (SD = 13.4) and 31.7% were female. Self-reported cognitive function among survivors was reported as: ‘Much worse’ by 3.1%, ‘Worse’ by 23.8%, ‘Unchanged’ by 68.3%, ‘Better’ by 3.3%, and ‘Much better’ by 1.5%. Declined cognitive function was associated with lower health status (OR = 2.76, 95% CI = 2.09–3.64), symptoms of anxiety (OR = 3.84, 95% CI = 2.80–5.24) and depression (OR = 4.52, 95% CI = 3.22–6.32), and being dissatisfied with overall life (OR = 2.74, 95% CI = 2.11–3.54). These associations remained significant after age, sex, place of CA, aetiology, initial rhythm, initial witnessed status, and cerebral performance were controlled.

Conclusions

Survivors experiencing declined cognitive function post-CA are at a higher risk of poorer health status, increased psychological distress, and reduced life satisfaction, and these risks should be acknowledged by healthcare professionals.
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引用次数: 0
期刊
Resuscitation
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