The relationship between dietary inflammatory index in adults and coronary heart disease: from NHANES 1999-2018.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS Frontiers in Nutrition Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1564580

Hong Xu, Pengxin Xie, Hui Liu, Zhenyu Tian, Ruitao Zhang, Ming Cui

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Abstract

Background: Previous studies have shown that pro-inflammatory diets increase the risk of coronary heart disease (CHD) and all-cause mortality. The dietary inflammatory index (DII) is a quantitative measure of dietary inflammation, and its accuracy has been validated by several studies.

Methods: This study included 43,842 participants aged ≥18 years from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. The data of CHD was obtained through a questionnaire survey, and the DII was calculated using 24-h dietary recall data. Generalized linear models and logistic regression were used to determine the mediation factors, and subgroup analyses were conducted to evaluate the interaction between DII and CHD. Mean decrease in Gini (MDG) was used to determine the importance of individual dietary components.

Results: The age of the participants was 49.81 ± 18.10 years, with 20,793 (47.4%) being male. A total of 1,892 (4.3%) participants were diagnosed with CHD, and the median DII score was 1.33 (0.11, 2.40). After adjusting for potential confounders, logistic regression analysis revealed that DII independently associated with CHD [OR: 1.049 (1.012-1.087), p = 0.008]. Triglyceride-glucose index, visceral adiposity index, body mass index, waist-to-height ratio, high-density lipoprotein, and glomerular filtration rate (all p < 0.05) may mediate the relationship between DII and CHD. Subgroup analyses showed that DII was more sensitive in participants aged <75 years (p < 0.001), females (p = 0.028), those with low cholesterol levels (p = 0.004), and individuals with low Framingham risk scores (p = 0.005). MDG analysis indicated that carbohydrate, vitamin C and iron intake have the greatest impact on CHD.

Conclusion: This study suggests that various metabolic and lipid indicators play a mediating role in the relationship between DII and CHD. DII may have a greater adverse impact on traditional low-risk CHD populations.

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成人饮食炎症指数与冠心病的关系：来自NHANES 1999-2018

背景：先前的研究表明，促炎饮食会增加冠心病（CHD）和全因死亡率的风险。膳食炎症指数（DII）是一种定量衡量膳食炎症的指标，其准确性已得到多项研究的验证。方法：本研究纳入了1999-2018年国家健康与营养调查（NHANES）中年龄≥18 岁的43,842名参与者。CHD数据通过问卷调查获得，DII采用24 h饮食回忆数据计算。采用广义线性模型和逻辑回归来确定中介因素，并进行亚组分析来评估DII与冠心病之间的相互作用。基尼系数的平均下降（MDG）被用来确定单个饮食成分的重要性。结果：参与者年龄49.81 ± 18.10 岁，男性20,793人（47.4%）。共有1892名（4.3%）参与者被诊断为冠心病，中位DII评分为1.33（0.11,2.40）。在调整潜在混杂因素后，logistic回归分析显示DII与冠心病独立相关[OR: 1.049 (1.012-1.087), p = 0.008]。甘油三酯-葡萄糖指数、内脏脂肪指数、体重指数、腰高比、高密度脂蛋白和肾小球滤过率（p均为 p p = 0.028）、低胆固醇水平（p = 0.004）和低Framingham风险评分（p = 0.005）的个体。千年发展目标分析表明，碳水化合物、维生素C和铁的摄入对冠心病的影响最大。结论：本研究提示多种代谢和脂质指标在DII与冠心病的关系中起中介作用。DII可能对传统低风险冠心病人群有更大的不利影响。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.