The Development and Challenges of PET/MRI Dual-Modality Imaging Probes—An Update

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Journal of Magnetic Resonance Imaging Pub Date : 2025-04-07 DOI:10.1002/jmri.29779

Maryam Sabbaghan, Saumya Nigam, Isabella Kasabasic, Medha Manepalli, Ping Wang, Jinda Fan

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Abstract

The integration of Positron emission tomography (PET) with Magnetic resonance imaging (MRI) combines the functional imaging capabilities of PET with the high-resolution anatomical detail of MRI, creating a synergistic platform for advanced diagnostic imaging and image-guided therapies. Central to the success of this dual-modality system is the development of specialized PET/MRI dual-modality probes, particularly those capable of simultaneous functionality, which present significant technical challenges in synthesis and applications. This review explores the advancements in PET/MRI probe development, summarizes the current applications, and highlights the critical challenges in translating PET/MRI probes from experimental research to clinical applications, offering insights into the future direction of this transformative imaging technology.

Evidence Level

Technical Efficacy

Stage 1.

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PET/MRI双模成像探针的发展与挑战

正电子发射断层扫描（PET）与磁共振成像（MRI）的整合将PET的功能成像能力与MRI的高分辨率解剖细节相结合，为先进的诊断成像和图像引导治疗创造了一个协同平台。这种双模态系统成功的核心是专用PET/MRI双模态探针的开发，特别是那些能够同时发挥功能的探针，这在合成和应用方面提出了重大的技术挑战。本文综述了PET/MRI探针的发展进展，总结了目前的应用情况，并强调了将PET/MRI探针从实验研究转化为临床应用的关键挑战，为这一变革性成像技术的未来发展方向提供了见解。证据等级：5。技术功效：第一阶段。

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来源期刊

Journal of Magnetic Resonance Imaging 医学-核医学

CiteScore

9.70

自引率

6.80%

发文量

494

审稿时长

2 months

期刊介绍： The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.