Ali Ibrahim Shkhair, Anju S Madanan, Susan Varghese, Merin K Abraham, Geneva Indongo, Greeshma Rajeevan, Arathy B K, Sara Muneer Abbas, Sony George
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引用次数: 0
Abstract
Breast cancer continues to be a complicated and pervasive health issue that impacts women worldwide. Fluorescent nanoparticles, in particular, provide significant potential for imaging and drug delivery in cancer cells. We describe the utilization of o-phenylenediamine carbon nanodots (OPD@CD) as fluorescent agents for in vitro imaging and drug delivery of breast cancer cells. The surface of OPD@CD was modified with the tyrosine kinase inhibition anticancer drug - erlotinib. The drug specifically targets human breast cancer cell lines (MCF-7) that overexpress the epidermal growth factor receptor (EGFR). The confocal luminescence microscopic photographs exhibit sufficient luminescence staining in MCF-7 cells.
期刊介绍：
Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.
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