Probiotic use reduces the incidence of antibiotic-associated diarrhea among adult patients: a meta-analysis.

IF 2.5 Q3 GASTROENTEROLOGY & HEPATOLOGY Przegla̜d Gastroenterologiczny Pub Date : 2025-01-01 Epub Date: 2025-03-16 DOI:10.5114/pg.2025.148486

Henry Wanyama, Tayyab S Akhtar, Sameen Abbas

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Abstract

Introduction: Probiotics potentially mitigate diarrhea incidence and severity, but their effectiveness in antibiotic-associated diarrhea (AAD) remains debated.

Aim: This meta-analysis aimed to enhance evidence on probiotic use for AAD.Methods: A systematic search of randomized controlled trials (RCTs) from 2010 to 2023 in PubMed, EMBASE, Scopus, and Google Scholar was conducted. Eligible studies underwent risk assessment with the RoB-2 tool and data extraction using the random effects model. Subgroup analyses evaluated age, sample size, and probiotic strains' influence.

Results: Fifteen trials with 7427 participants were included. Overall quality was moderate. Pooled analysis favored probiotics, reducing AAD incidence by 40% (RR = 0.60, 95% CI: 0.43-0.82). This effect was consistent across subgroup analyses. Multistrain probiotics showed superior protection (RR = 0.40 vs. 0.9 or 0.6 for dual or single strains).

Conclusions: This review suggests that probiotics, especially multistrain combinations, mitigate AAD incidence. Future large-scale RCTs will address heterogeneity.

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益生菌的使用降低了成人患者抗生素相关性腹泻的发生率：一项荟萃分析。

益生菌可能减轻腹泻的发生率和严重程度，但它们在抗生素相关性腹泻（AAD）中的有效性仍存在争议。目的：本荟萃分析旨在加强益生菌治疗AAD的证据。方法：系统检索PubMed、EMBASE、Scopus和谷歌Scholar中2010 - 2023年的随机对照试验（RCTs）。使用rob2工具对符合条件的研究进行风险评估，并使用随机效应模型提取数据。亚组分析评估了年龄、样本量和益生菌菌株的影响。结果：纳入15项试验，共7427名受试者。整体质量一般。综合分析表明，益生菌可使AAD发病率降低40% （RR = 0.60, 95% CI: 0.43-0.82）。这种效应在亚组分析中是一致的。多菌种益生菌具有较好的保护作用（RR = 0.40，而双菌种和单菌种的RR分别为0.9和0.6）。结论：这篇综述表明益生菌，特别是多菌株组合，可以减轻AAD的发病率。未来的大规模随机对照试验将解决异质性问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Przegla̜d Gastroenterologiczny GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

2.20

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Gastroenterology Review is a journal published each 2 months, aimed at gastroenterologists and general practitioners. Published under the patronage of Consultant in Gastroenterology and Polish Pancreatic Club.