Zn(II) and Co(II)-Based MOFs for Fe3+ion Fluorescence Sensing and Used as Metal Paclitaxel-gel Particles on Nasopharyngeal Carcinoma Treatment

Abstract

In this work, two coordination polymers (CPs) based on Co(II) and Zn(II), namely, [Zn(opbt)(1,3-bdc)(H₂O)]_n (1, opbt is 1,1′-(oxybis(1,4-phenylene))-bis(1H-1,2,4-triazole), 1,3-bdc²⁻ is 1,3-dicarboxylate) and [Co₂(opbt)₂(1,3-bdc)₂]_n (2) are produced via the mixed-ligand creation way through the reaction between the associated metal salt and the opbt ligand after utilizing carboxylic aid ligand 1,3-dicarboxylic acid. Furthermore, fluorescence tests demonstrated that both compounds exhibited excellent photoluminescent properties, emitting strong fluorescence at room temperature. With great selectivity and sensitivity, they may be applied as luminous sensors to determine Fe³⁺ in aqueous solutions. Based on the unique advantages of CPs as carriers, we have innovated a novel composite drug delivery system, hyaluronic acid (HA)/carboxymethyl chitosan (CMCS) hydrogel-CPs, for loading the classic anticancer drug paclitaxel. We conducted Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and Thermogravimetric Analysis (TGA) on the metal gel particles loaded with paclitaxel (HA/CMCS-CP_S@paclitaxel). Subsequently, their efficacy against nasopharyngeal carcinoma was compared, revealing significant inhibition of cancer cell proliferation by both types, with one exhibiting higher efficacy, thereby providing a new avenue for the treatment of nasopharyngeal carcinoma.