The stomach, small intestine, and colon-specific gastrointestinal tract delivery systems for bioactive nutrients

IF 19.3 1区化学 Q1 CHEMISTRY, PHYSICAL Advances in Colloid and Interface Science Pub Date : 2025-07-01 Epub Date: 2025-04-01 DOI:10.1016/j.cis.2025.103503

Shuang Liang , Dongyu Zhao , Xiangyu Liu , Bin Liu , Yuan Li

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Abstract

Oral administration is a convenient way to deliver bioactive nutrients. However, the complex and dynamic environment of the gastrointestinal (GI) tract poses distinct challenges. These include the acidic environment of the stomach, limited transport across the GI mucosa, and the risk of enzymatic degradation, all of which can compromise the nutritional effectiveness of orally delivered nutrients. In response to these challenges, various GI tract delivery systems have been developed to target specific regions, such as the stomach, small intestine, or colon, to precisely control the release of bioactive nutrients and enhance their health-promoting benefits. This review critically examines the principles underlying stomach-, small intestine-, and colon-targeted delivery systems, highlighting the selection of appropriate wall materials and the interactions between delivery systems and the mucosal epithelial barrier. Moreover, we describe relevant biological models and quantitative analyses to measure these interactions. In particular, we emphasize the significant advantages offered by colon-targeted delivery systems in maintaining a healthy colonic microenvironment. This review aims to inspire novel concepts and stimulate further research into GI tract delivery systems, offering promising avenues for maximizing the therapeutic effects of bioactive nutrients in practical applications.

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胃，小肠和结肠特异性胃肠道输送系统的生物活性营养素

口服给药是一种提供生物活性营养素的方便方法。然而，胃肠道的复杂和动态环境提出了不同的挑战。这些因素包括胃的酸性环境、通过胃肠道粘膜的运输受限以及酶降解的风险，所有这些都可能损害口服营养物质的营养效果。为了应对这些挑战，各种胃肠道输送系统已经开发出针对特定区域，如胃，小肠或结肠，以精确控制生物活性营养素的释放并增强其健康益处。本文综述了胃、小肠和结肠靶向给药系统的基本原理，重点介绍了合适的壁材料的选择以及给药系统与粘膜上皮屏障之间的相互作用。此外，我们描述了相关的生物学模型和定量分析来测量这些相互作用。我们特别强调结肠靶向给药系统在维持健康结肠微环境方面的显著优势。这篇综述旨在启发新的概念和刺激胃肠道输送系统的进一步研究，为生物活性营养素在实际应用中最大限度地发挥治疗效果提供有希望的途径。

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来源期刊

Advances in Colloid and Interface Science 化学-物理化学

CiteScore

28.50

自引率

2.60%

发文量

175

审稿时长

31 days

期刊介绍： "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.