{"title":"Beyond mechanosensing: How cells sense and shape their physical environment during development","authors":"Matyas Bubna-Litic, Roberto Mayor","doi":"10.1016/j.ceb.2025.102514","DOIUrl":null,"url":null,"abstract":"<div><div>The role of mechanics as a regulator of cell behaviour and embryo development has been widely recognised. However, much of the focus in mechanobiology during embryo development has been on how the mechanical properties of a cell affect its behaviour and fate determination. We discuss the role of mechanosignalling in development and propose that an equally important aspect of embryo mechanobiology is understanding how dynamic changes in tissue mechanics are regulated. Comparably to how chemical signals influence the fate of responding tissues during embryonic induction, we suggest that embryonic cell populations can alter the mechanical properties of adjacent tissues in a process we name ‘actuation’. Several examples of embryonic actuation and mechanical feedback are discussed.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102514"},"PeriodicalIF":4.3000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0955067425000523","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/10 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The role of mechanics as a regulator of cell behaviour and embryo development has been widely recognised. However, much of the focus in mechanobiology during embryo development has been on how the mechanical properties of a cell affect its behaviour and fate determination. We discuss the role of mechanosignalling in development and propose that an equally important aspect of embryo mechanobiology is understanding how dynamic changes in tissue mechanics are regulated. Comparably to how chemical signals influence the fate of responding tissues during embryonic induction, we suggest that embryonic cell populations can alter the mechanical properties of adjacent tissues in a process we name ‘actuation’. Several examples of embryonic actuation and mechanical feedback are discussed.
期刊介绍：
Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings.
COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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