Mitigating Cadmium Toxicity: Role of Caffeine in the Reduction of Oxidative Stress.

IF 1 Q3 VETERINARY SCIENCES Open Veterinary Journal Pub Date : 2025-02-01 Epub Date: 2025-02-28 DOI:10.5455/OVJ.2025.v15.i2.42

Ahmed Aljazzar

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Abstract

Background: Cadmium (Cd) is a common environmental pollutant that causes severe health issues. Many studies have proposed antioxidant foods to combat Cd toxicity. One such antioxidant agent is caffeine, and hence, this study investigated its effects.

Aim: To investigate the effect of caffeine as an antioxidant agent against Cd toxicity.

Methods: Twelve male albino mice were divided into three groups of four: Group 1: Administered 1 ml of saline orally for 7 days and injected with 1 ml of saline subcutaneously (S/C) on the eighth day. Group 2: Patients were orally administered 1 ml of saline for 7 days and injected with 1-ml of cadmium chloride (CdCl2) S/C on the eighth day. Group 3: Administered 1 ml of caffeine orally for seven days and injected with CdCl2 S/C on the eighth day.

Results: Results showed that caffeine can reduce Cd-induced testicular hemorrhage, lung injury, and kidney injury. Additionally, caffeine was found to significantly reduce the Cd-induced inflammatory response in lung-associated lymphoid tissue.

Conclusion: These findings suggest that the daily intake of caffeine could protect against Cd toxicity.

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减轻镉毒性：咖啡因在减少氧化应激中的作用。

背景：镉（Cd）是一种常见的环境污染物，会导致严重的健康问题。许多研究建议食用抗氧化食品来对抗镉的毒性。其中一种抗氧化剂是咖啡因，因此，本研究调查了它的作用。目的：探讨咖啡因抗镉中毒的作用。方法：将12只雄性白化小鼠分为3组，每组4只：1组：连续7天口服生理盐水1 ml，第8天皮下注射生理盐水1 ml （S/C）。2组：连续7天口服生理盐水1 ml，第8天注射氯化镉（CdCl2） S/C 1 ml。第三组：口服咖啡因1 ml，连续7天，第8天注射CdCl2 S/C。结果：咖啡因能减轻cd所致睾丸出血、肺损伤和肾损伤。此外，咖啡因被发现可以显著减少cd诱导的肺相关淋巴组织炎症反应。结论：每日摄入咖啡因可预防镉中毒。

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来源期刊

Open Veterinary Journal VETERINARY SCIENCES-

CiteScore

1.40

自引率

0.00%

发文量

112

审稿时长

12 weeks

期刊介绍： Open Veterinary Journal is a peer-reviewed international open access online and printed journal that publishes high-quality original research articles. reviews, short communications and case reports dedicated to all aspects of veterinary sciences and its related subjects. Research areas include the following: Infectious diseases of zoonotic/food-borne importance, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, epidemiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology, oncology and animal reproduction. All papers are peer-reviewed. Moreover, with the presence of well-qualified group of international referees, the process of publication will be done meticulously and to the highest standards.