{"title":"Mineralization of macroaggregated albumin for accurate biodistribution evaluation of pre-radiotherapy†","authors":"Xiaomin Gao , Mingru Zhang , Danlan Fang , Yuan Yu , Shaolong Qi , Xinyang Yu , Meiqi Cheng , Shoujun Zhu , Fei Kang , Kuikun Yang , Guocan Yu","doi":"10.1039/d5cc01204j","DOIUrl":null,"url":null,"abstract":"<div><div>Conventional macroaggregated albumin (MAA) often fails to accurately simulate the biodistribution of <sup>90</sup>Y microspheres in hepatic artery perfusion scintigraphy due to density mismatch. By mineralizing MAA, we developed lightly mineralized MAA (L-MAA) and highly mineralized MAA (H-MAA) with controlled densities, which enabled more accurate simulation of the biodistribution of resin and glass microspheres.</div></div>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"61 40","pages":"Pages 7313-7316"},"PeriodicalIF":4.2000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1359734525007992","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/10 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Conventional macroaggregated albumin (MAA) often fails to accurately simulate the biodistribution of 90Y microspheres in hepatic artery perfusion scintigraphy due to density mismatch. By mineralizing MAA, we developed lightly mineralized MAA (L-MAA) and highly mineralized MAA (H-MAA) with controlled densities, which enabled more accurate simulation of the biodistribution of resin and glass microspheres.
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