Magnetic-plasmonic nanoparticle-based surface-enhanced Raman scattering for biomedical detection

IF 4.6 2区化学 Q1 SPECTROSCOPY Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-04-06 DOI:10.1016/j.saa.2025.126177

Fengxue Wei , Yaling Liu

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Abstract

Surface-enhanced Raman scattering (SERS) is a powerful spectroscopic technique that enables rapid, non-destructive, and susceptible detection of biological samples. The magnetic-plasmonic composite materials composed of magnetic and plasmonic nanoparticles have attracted extensive attention as SERS substrates in the biomedical field because of their ability to enrich, separate, and selectively identify biomolecules. In this review, the state-of-art progress of magnetic-plasmonic nanoparticle (MPNP)-based SERS substrates for biomedical detection is highlighted, covering the design and construction of MPNPs with different morphologies, organic and inorganic surface functionalization strategies adopted to improve the adaptability and applicability in biological systems for MPNPs, application development of MPNPs in biomedical detection, as well as the future challenges and issues to be addressed. It is highly expected that this review will help to fully understand the research status of MPNP-based SERS substrates and facilitate their further development and wider application in biological systems.

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磁等离子体纳米粒子表面增强拉曼散射用于生物医学检测

表面增强拉曼散射（SERS）是一种强大的光谱技术，可以快速，非破坏性和敏感地检测生物样品。由磁性和等离子体纳米粒子组成的磁-等离子体复合材料由于具有富集、分离和选择性识别生物分子的能力，作为SERS底物在生物医学领域受到了广泛关注。本文综述了基于磁等离子体纳米粒子（MPNP）的生物医学检测SERS衬底的研究进展，包括不同形貌的MPNP的设计与构建、为提高MPNP在生物系统中的适应性和适用性而采用的有机和无机表面功能化策略、MPNP在生物医学检测中的应用发展以及未来面临的挑战和需要解决的问题。希望本文综述有助于全面了解基于mpnp的SERS底物的研究现状，促进其在生物系统中的进一步开发和广泛应用。

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来源期刊

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 物理-光谱学

CiteScore

8.40

自引率

11.40%

发文量

1364

审稿时长

40 days

期刊介绍： Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science. The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments. Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate. Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to: Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences, Novel experimental techniques or instrumentation for molecular spectroscopy, Novel theoretical and computational methods, Novel applications in photochemistry and photobiology, Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.