[18F]Radiolabeling fluorination of monofluoroalkyl triflates for the synthesis of [18F]difluoromethylated alkanes†

Abstract

An efficient method for the synthesis of [¹⁸F]-difluoromethylated alkanes by the combination of [¹⁸F]radio-fluoride with monofluoroalkyl triflates has been developed. This method uses [¹⁸F]KF/K_2.2.2 as the fluorine source. It features synthetic simplicity without tedious precursor preparation, high RCC and RCY, good functional group tolerance, and is silver salt-free, providing potential for developing new PET agents.