{"title":"Biosynthesis of nano-hydroxyapatite from potential probiotic Bacillus amyloliquefaciens and its effect on osteoblastic cells","authors":"Sabereh Nouri , Giti Emtiazi , Rasoul Roghanian , Songul Ulag , Oguzhan Gunduz","doi":"10.1016/j.matlet.2025.138549","DOIUrl":null,"url":null,"abstract":"<div><div>The eco-friendly synthesis of nano-biomaterials has gained prominence in bone disorder treatment. This study explores the green synthesis of nano-hydroxyapatite using <em>Bacillus amyloliquefaciens</em> and evaluates its biocompatibility and osteogenic potential in MG-63 and MC3T3-E1 cell lines. Characterization confirmed desirable crystallinity and elemental composition. The nanoparticles exhibited no significant toxicity over 21 days, enhancing matrix mineralization and alkaline phosphatase activity (0.44 U/mg in MG-63, 0.55 U/mg in MC3T3-E1). These findings highlight the potential of probiotic-derived nano-Hydroxyapatite for bone tissue engineering and regenerative medicine.</div></div>","PeriodicalId":384,"journal":{"name":"Materials Letters","volume":"392 ","pages":"Article 138549"},"PeriodicalIF":2.7000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Letters","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167577X25005786","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/11 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The eco-friendly synthesis of nano-biomaterials has gained prominence in bone disorder treatment. This study explores the green synthesis of nano-hydroxyapatite using Bacillus amyloliquefaciens and evaluates its biocompatibility and osteogenic potential in MG-63 and MC3T3-E1 cell lines. Characterization confirmed desirable crystallinity and elemental composition. The nanoparticles exhibited no significant toxicity over 21 days, enhancing matrix mineralization and alkaline phosphatase activity (0.44 U/mg in MG-63, 0.55 U/mg in MC3T3-E1). These findings highlight the potential of probiotic-derived nano-Hydroxyapatite for bone tissue engineering and regenerative medicine.
期刊介绍：
Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials.
Contributions include, but are not limited to, a variety of topics such as:
• Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors
• Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart
• Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction
• Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots.
• Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing.
• Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic
• Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive
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