Selective and sensitive detection of metronidazole in aquatic products using a novel fluorescent sensor based on lanthanide supramolecular framework

Abstract

Metronidazole (MDZ) is a broad-spectrum antibiotic effective against bacterial and protozoan infections in both humans and poultry farms. However, excessive intake of MDZ can lead to deleterious effects. Therefore, minimizing its environmental presence is crucial for maintaining daily life. In this study, a lanthanide supramolecular framework Tb_2.67(CB[5]₂)(SIP) (1) was synthesized. Based on the intense green luminescence of 1, it was utilized as a fluorescent sensor for MDZ detection, with the limit of detection (LOD) was 0.16 μM. Further applied research on the above content has shown that this probe can be used for the detection of MDZ in fish and shrimp, with satisfactory results. By incorporating smartphone applications, the hydrogel based on 1 achieves real-time, visualization and quantification detection of MDZ, providing a user-friendly and efficient detection method. This study offers a viable alternative approach for both qualitative and quantitative assessment of MDZ, ensuring the safety of food.