Development and Degradation Study of PLA-Based Medical Implant Markers for Magnetic Particle Imaging

IF 4.1 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Macromolecular bioscience Pub Date : 2025-04-14 DOI:10.1002/mabi.202570007

Patrick N. Elfers, Kerstin Lüdtke-Buzug, Ankit Malhotra, Justin Ackers, Liana Mirzojan, Maximilian Wattenberg, Johann C. Engster, David Melenberg, Mandy Ahlborg, Thomas Friedrich, Maria-Josephina Buhné, Malte M. Sieren, Thorsten M. Buzug, Roman Kloeckner, Jörg Barkhausen, Franz Wegner

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Abstract

Front Cover: In article 2400495, Franz Wegner and co-workers develop and study medical instrument markers composed of polylactic acid (PLA) and superparamagnetic iron-oxide nanoparticles (SPIONs) for the emerging imaging technique, Magnetic Particle Imaging (MPI). Over a 28-day test period, more than 90% of the PLA degrade in the surrounding water. Consequently, these markers hold potential for the temporary visualization of endovascular instruments (e.g. vascular stents) in future medical applications of this currently preclinical method.

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基于pla的医用植入物磁颗粒成像标记物的研制与降解研究

封面：在文章2400495中，Franz Wegner及其同事开发和研究了用于新兴成像技术磁颗粒成像（MPI）的由聚乳酸（PLA）和超顺磁性氧化铁纳米颗粒（SPIONs）组成的医疗器械标记物。在28天的测试期间，超过90%的PLA在周围的水中降解。因此，这些标记物在目前临床前方法的未来医学应用中具有血管内器械（如血管支架）临时可视化的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Macromolecular bioscience 生物-材料科学：生物材料

CiteScore

7.90

自引率

2.20%

发文量

211

审稿时长

1.5 months

期刊介绍： Macromolecular Bioscience is a leading journal at the intersection of polymer and materials sciences with life science and medicine. With an Impact Factor of 2.895 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)), it is currently ranked among the top biomaterials and polymer journals. Macromolecular Bioscience offers an attractive mixture of high-quality Reviews, Feature Articles, Communications, and Full Papers. With average reviewing times below 30 days, publication times of 2.5 months and listing in all major indices, including Medline, Macromolecular Bioscience is the journal of choice for your best contributions at the intersection of polymer and life sciences.