Suitability of a BeO-based OSLD system for end-to-end remote dosimetry tests in SRS/SRT applications

IF 2.7 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Physica Medica-European Journal of Medical Physics Pub Date : 2025-04-14 DOI:10.1016/j.ejmp.2025.104975
Alexandra Drakopoulou , Polymnia Glampedaki , Vasiliki Peppa , Efi Koutsouveli , Georgios Kollias , Pantelis Karaiskos , Eleftherios P. Pappas
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Abstract

Purpose

The aim of this study is to evaluate the suitability of a commercially available Optically Stimulated Luminescence Dosimetry (OSLD) system for remote dosimetry end-to-end tests in Stereotactic Radiosurgery and Radiotherapy (SRS/SRT). This is achieved by performing a dose–response characterization focusing on the relevant irradiation and readout conditions, followed by dosimetry protocol development and implementation.

Methods

The myOSLchipTM Beryllium Oxide- (BeO-) based OSLD system (RadPro, Germany) was employed throughout this study. Measurements were performed to assess element sensitivity, signal depletion, linearity (up to 16 Gy), potential beam quality (6MV and 10MV) and angular dependence, signal fading rate, and potential sensitivity changes with lifetime accumulated dose (up to 98 Gy). Correction factors and uncertainties were determined following the AAPM TG-191 recommendations. The dosimetry system and protocol were implemented in an end-to-end remote dosimetry test, considering a clinically realistic single-isocenter multiple brain metastases case. For this purpose, 17 dosimeters were placed in a head phantom involving bone-mimicking inhomogeneities.

Results

A fixed depletion correction factor may not be applicable to all OSLDs. In 6MV, a sublinear dose–response behavior (up to 5%) was observed for the dose range, reader and readout parameters investigated, while an edge-on irradiation resulted in a 2.8% under-response compared to en face. OSLD sensitivity was stable up to at least 98 Gy of accumulated dose. Overall spatial and dosimetric experimental uncertainties in the end-to-end test were estimated at 0.6 mm and 3%, respectively. The local gamma index passing rate was 100%.

Conclusion

The evaluated OSLD system is suitable for end-to-end tests in SRS/SRT. This study can serve as an implementation guide in such applications.
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基于beo的OSLD系统在SRS/SRT应用中端到端远程剂量学测试的适用性
本研究的目的是评估市售光激发发光剂量测定(OSLD)系统在立体定向放射外科和放疗(SRS/SRT)中远程剂量测定端到端测试的适用性。这是通过对相关辐照和读出条件进行剂量反应表征,然后制定和实施剂量测定方案来实现的。方法采用myOSLchipTM氧化铍- (BeO-)基OSLD系统(德国RadPro公司)。测量结果包括元件灵敏度、信号损耗、线性度(高达16 Gy)、电位光束质量(6MV和10MV)和角度依赖性、信号衰减率和电位灵敏度随寿命累积剂量(高达98 Gy)的变化。根据AAPM TG-191建议确定校正因子和不确定性。考虑到临床实际的单等中心多发脑转移病例,剂量测定系统和方案在端到端远程剂量测定试验中实施。为此,17个剂量计被放置在一个涉及骨模拟不均匀性的头部幻影中。结果固定损耗校正因子不一定适用于所有的osld。在6MV下,剂量范围、读取器和读出参数的亚线性剂量反应行为(高达5%)被观察到,而与正面照射相比,侧面照射导致2.8%的低响应。OSLD的敏感性在至少98 Gy的累积剂量下是稳定的。端到端试验的总体空间和剂量学实验不确定性估计分别为0.6 mm和3%。局部伽玛指数合格率为100%。结论评价的OSLD系统适用于SRS/SRT的端到端检测。本研究可作为此类应用的实施指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.80
自引率
14.70%
发文量
493
审稿时长
78 days
期刊介绍: Physica Medica, European Journal of Medical Physics, publishing with Elsevier from 2007, provides an international forum for research and reviews on the following main topics: Medical Imaging Radiation Therapy Radiation Protection Measuring Systems and Signal Processing Education and training in Medical Physics Professional issues in Medical Physics.
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