Evaluating the impact of influenza vaccine on preventing stroke hospitalization and death in Chinese elderly hypertensive patients: A retrospective cohort study

IF 4.5 3区医学 Q2 IMMUNOLOGY Vaccine Pub Date : 2025-04-15 DOI:10.1016/j.vaccine.2025.127004

Feng Tong , Tianshu Zhou , Ling Tang , Xiaoqing Wu , Tianchi Yang , Lixia Ye

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Abstract

Background

The effect of influenza vaccination on stroke remains controversial, particularly given the paucity of studies conducted in mainland China.

Methods

Using a comprehensive database obtained from the Regional Health Information Platform, we conducted a 7-month retrospective cohort analysis of 457,887 elderly individuals residing in an eastern Chinese city. Using multivariate competing risks regression analysis, we derived subdistribution hazard ratios (sHRs) along with the corresponding 95 % confidence intervals (CIs).

Results

There was no significant difference in the proportion of hospitalizations for stroke between those who received the influenza vaccine and those who did not (7.50 per 1000 vs. 8.12 per 1000; adjusted sHR: 0.96, 95 % CI: 0.90–1.02). However, a pronounced reduction in stroke-related mortality was observed among vaccinated individuals, with a rate of 0.18 ‰ compared with 0.54 ‰ among the unvaccinated (adjusted sHR: 0.47, 95 % CI: 0.33–0.69).

Conclusion

This study highlights the substantial role of influenza vaccination in reducing the risk of stroke-related mortality in elderly hypertensive patients. Therefore, efforts to increase influenza vaccination rates in this population are strongly encouraged.

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评估流感疫苗对预防中国老年高血压患者中风住院和死亡的影响：回顾性队列研究

流感疫苗接种对脑卒中的影响仍然存在争议，特别是考虑到在中国大陆进行的研究的缺乏。方法利用从区域健康信息平台获得的综合数据库，对中国东部某城市457,887名老年人进行了为期7个月的回顾性队列分析。使用多变量竞争风险回归分析，我们导出了亚分布风险比（sHRs）以及相应的95%置信区间（ci）。结果接种流感疫苗的患者和未接种流感疫苗的患者因中风住院的比例无显著差异(7.50 / 1000 vs 8.12 / 1000；调整后sHR: 0.96, 95% CI: 0.90-1.02)。然而，在接种疫苗的人群中，中风相关死亡率显著降低，为0.18‰，而未接种疫苗的人群为0.54‰（调整后的sHR: 0.47, 95% CI: 0.33-0.69）。结论流感疫苗接种对降低老年高血压患者卒中相关死亡风险具有重要作用。因此，强烈鼓励在这一人群中努力提高流感疫苗接种率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

期刊介绍： Vaccine is unique in publishing the highest quality science across all disciplines relevant to the field of vaccinology - all original article submissions across basic and clinical research, vaccine manufacturing, history, public policy, behavioral science and ethics, social sciences, safety, and many other related areas are welcomed. The submission categories as given in the Guide for Authors indicate where we receive the most papers. Papers outside these major areas are also welcome and authors are encouraged to contact us with specific questions.