Front Cover: Redox-Responsive Side Chain Structural Changes in a Seven-Membered Cyclic α,α-Disubstituted α-Amino Acid with a Disulfide Bond Enable Reversible Conformational Changes in Peptides (ChemPlusChem 4/2025)
Dr. Makoto Oba, Hikaru Nonaka, Dr. Tomohiro Umeno, Dr. Takuma Kato, Dr. Mitsunobu Doi, Dr. Atsushi Ueda, Dr. Masakazu Tanaka
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引用次数: 0
Abstract
The front cover shows how redox-responsive side chain structural changes in amino acids enable reversible conformational transitions in peptides. Peptides incorporating cyclic amino acids with a disulfide adopt predominantly a well-defined 310-helical conformation in solution. In contrast, peptides containing acyclic amino acids with two thiol groups exhibit a diverse structural ensemble, consisting of both helical and non-helical conformations. More information can be found in the Research Article by Makoto Oba, Masakazu Tanaka, and co-workers (DOI: 10.1002/cplu.202400772).
期刊介绍：
ChemPlusChem is a peer-reviewed, general chemistry journal that brings readers the very best in multidisciplinary research centering on chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
Fully comprehensive in its scope, ChemPlusChem publishes articles covering new results from at least two different aspects (subfields) of chemistry or one of chemistry and one of another scientific discipline (one chemistry topic plus another one, hence the title ChemPlusChem). All suitable submissions undergo balanced peer review by experts in the field to ensure the highest quality, originality, relevance, significance, and validity.
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