Investigation of whether renal tumours with caval thrombi induce particular risks: a multicentre study (UroCCR-174 CAVORISK)

IF 4.4 2区医学 Q1 UROLOGY & NEPHROLOGY BJU International Pub Date : 2025-04-14 DOI:10.1111/bju.16739

Adrien Panis, Thibaut Waeckel, Karim Bensalah, Pierre Bigot, Louis Surlemont, Franck Bruyere, Nicolas Doumerc, Fayek Taha, Jonathan Olivier, Jean-Jacques Patard, Alexis Fontenil, Nicolas Branger, Romain Boissier, Pierre Merlin, Maxime Vallee, Clément Sarrazin, Norbert De Brek, Benjamin Rouget, Jean-Christophe Bernhard, Alexandre Ingels

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Abstract

Objective

To compare outcomes of nephrectomy for left-sided (n = 70) vs right-sided (n = 118) renal tumours with caval thrombi.

Methods

In this retrospective analysis (June 2008–February 2023), we evaluated peri-operative variables, 30-day complications, estimated glomerular filtration rate (eGFR), and survival rates.

Results

Patients in the left-sided renal tumour group experienced significantly longer operating times (240 vs 193 min; P < 0.001), greater blood loss (1700 vs 1000 mL, P = 0.042), and more complications (53% vs 35%, P = 0.015). Postoperative renal function was worse in the left-sided vs the right-sided renal tumour group, with lower immediate postoperative eGFR (P = 0.035) and a higher dialysis rate (17% vs 6.8%, P = 0.026). However, overall survival and recurrence-free survival were similar (P = 0.8 and P = 0.43, respectively).

Conclusions

Left-sided renal tumours with caval thrombi present a higher risk of complications and acute kidney injury requiring dialysis, potentially due to left renal vein ischaemia during surgery and anatomical proximity to the superior mesenteric artery. Thorough preoperative planning and limited clamping time are essential.

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肾肿瘤合并腔静脉血栓是否会诱发特殊风险的研究：一项多中心研究（urocr -174 CAVORISK）

比较左侧（n = 70）与右侧（n = 118）伴有腔静脉血栓的肾肿瘤行肾切除术的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BJU International 医学-泌尿学与肾脏学

CiteScore

9.10

自引率

4.40%

发文量

262

审稿时长

1 months

期刊介绍： BJUI is one of the most highly respected medical journals in the world, with a truly international range of published papers and appeal. Every issue gives invaluable practical information in the form of original articles, reviews, comments, surgical education articles, and translational science articles in the field of urology. BJUI employs topical sections, and is in full colour, making it easier to browse or search for something specific.