Novel specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil in duplex DNA†

IF 3.3 3区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Dalton Transactions Pub Date : 2025-04-15 DOI:10.1039/D5DT00619H
Hidetaka Torigoe, Kei Hirabayashi, Saki Adachi and Jiro Kondo
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Abstract

Only mercury(II) and silver(I) ions are known to specifically bind to natural and naturally modified base pairs in duplex DNA to form metal-mediated base pairs. We found novel, specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil (FdU) in duplex DNA, forming C–Cu–FdU and FdU–Cu–C base pairs.

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铜离子与双链DNA中5-氟尿嘧啶自然修饰碱基对的新型特异性结合
只有汞(II)和银(I)离子特异性地与双链DNA中的天然和自然修饰的碱基对结合,形成金属介导的碱基对。我们发现铜离子与双链DNA中含有5-氟尿嘧啶(FdU)的自然修饰碱基对结合形成C-Cu-FdU和FdU - cu - c。
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来源期刊
Dalton Transactions
Dalton Transactions 化学-无机化学与核化学
CiteScore
6.60
自引率
7.50%
发文量
1832
审稿时长
1.5 months
期刊介绍: Dalton Transactions is a journal for all areas of inorganic chemistry, which encompasses the organometallic, bioinorganic and materials chemistry of the elements, with applications including synthesis, catalysis, energy conversion/storage, electrical devices and medicine. Dalton Transactions welcomes high-quality, original submissions in all of these areas and more, where the advancement of knowledge in inorganic chemistry is significant.
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