Hidetaka Torigoe, Kei Hirabayashi, Saki Adachi and Jiro Kondo
{"title":"Novel specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil in duplex DNA†","authors":"Hidetaka Torigoe, Kei Hirabayashi, Saki Adachi and Jiro Kondo","doi":"10.1039/D5DT00619H","DOIUrl":null,"url":null,"abstract":"<p >Only mercury(<small>II</small>) and silver(<small>I</small>) ions are known to specifically bind to natural and naturally modified base pairs in duplex DNA to form metal-mediated base pairs. We found novel, specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil (FdU) in duplex DNA, forming C–Cu–FdU and FdU–Cu–C base pairs.</p>","PeriodicalId":71,"journal":{"name":"Dalton Transactions","volume":" 18","pages":" 7208-7213"},"PeriodicalIF":3.3000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/dt/d5dt00619h?page=search","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dalton Transactions","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/dt/d5dt00619h","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
Only mercury(II) and silver(I) ions are known to specifically bind to natural and naturally modified base pairs in duplex DNA to form metal-mediated base pairs. We found novel, specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil (FdU) in duplex DNA, forming C–Cu–FdU and FdU–Cu–C base pairs.
期刊介绍:
Dalton Transactions is a journal for all areas of inorganic chemistry, which encompasses the organometallic, bioinorganic and materials chemistry of the elements, with applications including synthesis, catalysis, energy conversion/storage, electrical devices and medicine. Dalton Transactions welcomes high-quality, original submissions in all of these areas and more, where the advancement of knowledge in inorganic chemistry is significant.