Sulfonated covalent organic frameworks (COF)/polyethersulfone (PES) membrane with enhanced hemocompatibility for blood oxygenation

IF 5.6 2区医学 Q1 BIOPHYSICS Colloids and Surfaces B: Biointerfaces Pub Date : 2025-04-16 DOI:10.1016/j.colsurfb.2025.114716

Yue Huang , Lunhao Zhi , Chong Cheng , Qiang Wei , Shudong Sun , Changsheng Zhao

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Abstract

In extracorporeal membrane oxygenation (ECMO) treatment, designing membrane with self-anticoagulant properties can solve problems resulting from the adverse effect of anticoagulants. In this study, 2,4,6-Triformylphloroglucinol (Tp) and 2,5-Diaminobenzenesulfonic acid (Pa-SO₃H) were applied to grow a sulfonated COF film in situ on the polyethersulfone (PES) membrane. The introduction of sulfonic groups increased the hydrophilicity and electronegativity of the TpPa COF film, improved its anti-protein adhesion properties, maintained the normal morphology of blood cells, and endowed the COF film with antithrombotic properties. In the porcine blood circulation test, the duration to increase So₂ (O₂ saturation) from ∼75–95 % in TpPa-SO₃H COF/PES membrane (M-TpPa-SO₃H) was 70 min shorter than that in TpPa COF/PES membrane (M-TpPa). This preparation method is applicable to the preparation of not only flat membranes, but also hollow fiber membranes. These findings emphasize the potential of M-TpPa-SO₃H in ECMO applications, providing superior antithrombotic property and CO₂ efflux potential.

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磺化共价有机框架(COF)/聚醚砜（PES）膜与增强血液相容性的血液氧合

在体外膜氧合（extracorporeal membrane oxygenation， ECMO）治疗中，设计具有自身抗凝性能的膜可以解决抗凝剂不良反应带来的问题。在本研究中，2,4,6-三甲酰间苯三酚（Tp）和2,5-二氨基苯磺酸（Pa-SO3H）在聚醚砜（PES）膜上原位生长磺化COF膜。巯基的引入增加了TpPa COF膜的亲水性和电负性，提高了其抗蛋白粘附性能，维持了血细胞的正常形态，赋予了COF膜抗血栓的特性。在猪血液循环试验中，TpPa- so3h COF/PES膜（M-TpPa- so3h）将So2 （O2饱和度）从~ 75-95 %提高的时间比TpPa- COF/PES膜（M-TpPa）短70 min。该制备方法不仅适用于平面膜的制备，也适用于中空纤维膜的制备。这些发现强调了M-TpPa-SO3H在ECMO应用中的潜力，提供了优越的抗血栓特性和二氧化碳排出潜力。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.