Xiao-Ning Liu , Yue-Tong Zhu , Bo-Tao Lu , Yong-Xian Cheng , Yan-Zhi Wang
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引用次数: 0
Abstract
The phytochemical investigation of the fruits of Alpinia oxyphylla Miq. led to the isolation and identification of seventeen structurally diverse compounds, including one undescribed carbonyl compound (1) and two new glycosides (6 and 10) together with fourteen known compounds. Their structures were assigned by spectroscopic and computational methods combined with acid hydrolysis. Nine compounds (1, 2, 6, 8, 10, 11, 14, 15 and 17) displayed inhibitory activities to renal fibrosis in TGF-β1 induced kidney proximal tubular cells, and a dose-effect relationship was observed in compounds 2, 6 and 10. The antifibrotic mechanism of compound 10 was related to the inhibition of phosphorylation of Smad2/3.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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