{"title":"Advances in cyclodextrin-based materials: Anticancer and antimicrobial applications–A review (2021–2024)","authors":"Alaa Shafie , Amal Adnan Ashour","doi":"10.1016/j.microc.2025.113672","DOIUrl":null,"url":null,"abstract":"<div><div>Cyclodextrins (CDs) have garnered significant interest in medicinal chemistry due to their ability to enhance the solubility, stability, and bioavailability of therapeutic agents. Their unique structural properties allow for the formation of inclusion complexes, which improve drug delivery efficiency and therapeutic outcomes. Recent advancements have demonstrated the dual potential of CDs in anticancer and antimicrobial applications, where they contribute to controlled drug release, reduced toxicity, and enhanced efficacy. By optimizing drug formulations, CDs play a crucial role in overcoming challenges associated with solubility-limited drugs, thereby supporting modern therapeutic approaches. This review explores the latest innovations in CD-based drug delivery, emphasizing their impact on both cancer treatment and antimicrobial strategies. With increasing research efforts dedicated to developing CD-based formulations, their role in healthcare continues to expand, offering new opportunities for improved drug design and patient outcomes.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"213 ","pages":"Article 113672"},"PeriodicalIF":4.9000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchemical Journal","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0026265X25010264","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/16 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Cyclodextrins (CDs) have garnered significant interest in medicinal chemistry due to their ability to enhance the solubility, stability, and bioavailability of therapeutic agents. Their unique structural properties allow for the formation of inclusion complexes, which improve drug delivery efficiency and therapeutic outcomes. Recent advancements have demonstrated the dual potential of CDs in anticancer and antimicrobial applications, where they contribute to controlled drug release, reduced toxicity, and enhanced efficacy. By optimizing drug formulations, CDs play a crucial role in overcoming challenges associated with solubility-limited drugs, thereby supporting modern therapeutic approaches. This review explores the latest innovations in CD-based drug delivery, emphasizing their impact on both cancer treatment and antimicrobial strategies. With increasing research efforts dedicated to developing CD-based formulations, their role in healthcare continues to expand, offering new opportunities for improved drug design and patient outcomes.
期刊介绍：
The Microchemical Journal is a peer reviewed journal devoted to all aspects and phases of analytical chemistry and chemical analysis. The Microchemical Journal publishes articles which are at the forefront of modern analytical chemistry and cover innovations in the techniques to the finest possible limits. This includes fundamental aspects, instrumentation, new developments, innovative and novel methods and applications including environmental and clinical field.
Traditional classical analytical methods such as spectrophotometry and titrimetry as well as established instrumentation methods such as flame and graphite furnace atomic absorption spectrometry, gas chromatography, and modified glassy or carbon electrode electrochemical methods will be considered, provided they show significant improvements and novelty compared to the established methods.
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