The effects of methyl nutrients on cognition and one carbon metabolism in older adults with mild cognitive impairment, A systematic review and meta-analysis

IF 2.4 3区医学 Q3 GERIATRICS & GERONTOLOGY Geriatric Nursing Pub Date : 2025-05-01 Epub Date: 2025-04-17 DOI:10.1016/j.gerinurse.2025.03.038

Yan Zhao , Yingling Ge , Zixuan Zhang , Chang Tan , Yingjing Lu , Xiaojing Guo , Yajie Tian , Xiaobei Feng , Yulin Wu , Sha Li , Huixian Cui

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Abstract

Background

Methyl nutrients can influence the one-carbon metabolic cycle and are important for cognitive function in older adults. We aimed to evaluate the effects of methyl nutrient supplementation, including the combination of folate and vitamin B12, and folate or vitamin B12 alone, on cognitive function and one-carbon metabolism in older adults with mild cognitive impairment.

Methods

Data were retrieved and collected from six electronic databases. Two authors independently appraised the methodological quality of included studies. Network meta-analysis was performed using the Bayesian method, R software.

Results

The combined intervention of folate and vitamin B12 is an effective type of nutrient intervention to slow cognitive decline in the elderly with MCI, reduce serum homocysteine concentration, and elevate serum folate and vitamin B12 concentrations.

Conclusion

Combining vitamin B12 plus folate supplementation is the best option for improving cognitive function in older adults with MCI.

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甲基营养素对老年轻度认知障碍患者认知和一碳代谢的影响，系统综述和荟萃分析

甲基营养素可以影响单碳代谢循环，对老年人的认知功能很重要。我们的目的是评估甲基营养素补充，包括叶酸和维生素B12的组合，以及叶酸或维生素B12单独，对轻度认知障碍老年人认知功能和单碳代谢的影响。方法从6个电子数据库中检索数据。两位作者独立评价了纳入研究的方法学质量。网络荟萃分析采用贝叶斯方法，R软件。结果叶酸和维生素B12联合干预是减缓老年轻度认知损伤认知能力下降、降低血清同型半胱氨酸水平、提高血清叶酸和维生素B12水平的有效营养干预方式。结论维生素B12联合叶酸补充剂是改善老年轻度认知损伤患者认知功能的最佳选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Geriatric Nursing 医学-护理

CiteScore

3.80

自引率

7.40%

发文量

257

审稿时长

>12 weeks

期刊介绍： Geriatric Nursing is a comprehensive source for clinical information and management advice relating to the care of older adults. The journal''s peer-reviewed articles report the latest developments in the management of acute and chronic disorders and provide practical advice on care of older adults across the long term continuum. Geriatric Nursing addresses current issues related to drugs, advance directives, staff development and management, legal issues, client and caregiver education, infection control, and other topics. The journal is written specifically for nurses and nurse practitioners who work with older adults in any care setting.