High-resolution prosthetic hearing with a soft auditory brainstem implant in macaques

IF 26.8 1区医学 Q1 ENGINEERING, BIOMEDICAL Nature Biomedical Engineering Pub Date : 2025-04-18 DOI:10.1038/s41551-025-01378-9

Alix Trouillet, Emilie Revol, Florent-Valéry Coen, Florian Fallegger, Aurélie Chanthany, Maude Delacombaz, Laurine Kolly, Ivan Furfaro, Florian Lanz, Vivek Kanumuri, Victor Adenis, Alejandro Garcia-Chavez, M. Christian Brown, Lukas Anschuetz, Jocelyne Bloch, Daniel J. Lee, Stéphanie P. Lacour

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Abstract

Individuals with compromised cochlear nerves are ineligible for cochlear implants and instead rely on auditory brainstem implants (ABIs). Most users of ABIs experience sound awareness, which aids in lip reading, yet not speech intelligibility. Here we engineered a dual-site (brainstem and cortex) implantable system, scaled to macaque anatomy, for the analysis of auditory perception evoked by electrical stimulation of the cochlear nucleus. A soft multichannel ABI, fabricated using thin-film processing, provided high-resolution auditory percepts, with spatially distinct stimulation sites eliciting cortical responses akin to frequency-specific tuning. Behavioural responses collected over several months were sufficiently precise to distinguish stimulations from adjacent channels. Soft multichannel ABIs may aid the rehabilitation of individuals with profound hearing loss who are ineligible for cochlear implants. Soft auditory brainstem implant in the cochlear nucleus of macaque evokes auditory-like perceptions with high resolution and tonotopic specificity.

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在猕猴身上植入软听觉脑干的高分辨率假肢听力

耳蜗神经受损的个体不适合人工耳蜗植入，而是依赖于听觉脑干植入（ABIs）。大多数ABIs用户都有声音意识，这有助于唇读，但不是语音可理解性。在这里，我们设计了一个双部位（脑干和皮层）植入式系统，按照猕猴的解剖结构进行缩放，用于分析电刺激耳蜗核引起的听觉感知。使用薄膜加工制造的软多通道ABI提供了高分辨率的听觉感知，具有空间不同的刺激位点，引发类似于频率特定调谐的皮层反应。几个月来收集的行为反应足够精确，可以区分相邻通道的刺激。软多通道ABIs可能有助于不适合人工耳蜗植入的重度听力损失患者的康复。

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来源期刊

Nature Biomedical Engineering Medicine-Medicine (miscellaneous)

CiteScore

45.30

自引率

1.10%

发文量

138

期刊介绍： Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.