Enhancing Mechanical Durability of Water-Soluble Microneedles with Cellulose Nanofibers via Thermal Imprinting

IF 8.2 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Applied Materials & Interfaces Pub Date : 2025-04-21 DOI:10.1021/acsami.5c02368
Tsubasa Ueda, Akihiko Nemoto, Akira Ishigami, Yutaka Kobayashi, Hiroshi Ito
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Abstract

The study demonstrates the effectiveness of ultrahigh-pressure homogenizer (UHPH) cellulose nanofibers (CNFs) in improving the mechanical properties of poly(vinyl alcohol) (PVA) microneedle arrays (MNA). CNFs were incorporated into PVA nanocomposite films at concentrations of 0, 5, and 8 wt % using solvent casting and a nickel mold coated with a fluoropolymer was used to thermally imprint the films with MNA micropatterns at optimal mold temperatures and pressing pressure. The integration of CNFs substantially enhanced the morphological properties, surface modulus, and the accuracy of pattern replication in the nanocomposite. The augmented mechanical strength observed in the micropatterns, attributed to CNFs and subjected to UHPH treatment, can be ascribed to the physical entanglement and hydrogen bonding facilitating formation within the MNA micropattern.

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热印迹法增强纤维素纳米纤维水溶性微针的机械耐久性
研究证明了超高压均质机(UHPH)纤维素纳米纤维(CNFs)在改善聚乙烯醇(PVA)微针阵列(MNA)力学性能方面的有效性。使用溶剂铸造将CNFs以0、5和8 wt %的浓度掺入PVA纳米复合膜中,并使用涂有含氟聚合物的镍模具在最佳模具温度和压力下用MNA微图案热压薄膜。CNFs的集成大大提高了纳米复合材料的形态特性、表面模量和图案复制的准确性。在微图案中观察到的机械强度增强,归因于CNFs并经过超高压处理,可归因于MNA微图案中促进形成的物理纠缠和氢键。
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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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