Anca Emanuela Minuti, Cristina Stavila, Adrian Ghemes, Oana-Georgiana Dragos-Pinzaru, Nicoleta Lupu, Horia Chiriac
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引用次数: 0
Abstract
This study explores the potential use of Co-Fe nanowires for the targeted destruction of cancer cells through a magnetomechanical effect. This research specifically focuses on the impact of nanowire composition, size, and magnetic properties on their efficacy in inducing cell death. Co-Fe nanowires, chosen for their high saturation magnetization and shape anisotropy, were tested against human osteosarcoma cells (HOS) and normal human fibroblasts (NHDF). The results demonstrated that Co-Fe nanowires could significantly reduce the viability of cancer cells through magnetomechanical actuation while having a less pronounced effect on normal cells. These findings suggest that Co-Fe nanowires (NWs) could be a viable tool in cancer therapy, leveraging their magnetic properties to target and destroy malignant cells selectively.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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