A ruthenium-nickel metal–organic framework incorporating 2,2'-bipyridine- 5,5'-dicarboxylic acid for dual-mode electrochemiluminescence-fluorescence detection of ferric ions

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL Microchimica Acta Pub Date : 2025-04-21 DOI:10.1007/s00604-025-07168-z

Jing Zhang, Zhaojiang Yin, Wei Xiong, QiQi Fan, Fengyao Yu, Fusheng Liao, Hao Fan, Fei Qu, Qiangqiang Yu

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Abstract

A novel, low-toxicity Ru-Ni-BPY metal–organic framework (MOF) nanomaterial was developed and a simple and sensitive dual-mode "on–off" ferric ions (Fe³⁺) sensing platform based on this material constructed. The dual-mode detection method enabled cross-validation of the electrochemiluminescence (ECL) and fluorescent (FL) signals, enhancing accuracy and effectively minimizing errors. In linear ranges of 0.005–10 μM and 0.078–10 μM, Fe³⁺ can dramatically quench the ECL and FL signals of the Ru-Ni-BPY MOF, with quenching rates of 91.42% and 91.31%, respectively, and detection limits of 0.1 nM and 9.3 nM, respectively. This ECL method not only achieved efficient detection of Fe³⁺ in rat brain microdialysis fluid but also successfully enabled real-time FL detection of Fe³⁺ in nude mice. Therefore, this platform has great potential for applications in environmental protection, life sciences, and early disease diagnosis.

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含2,2'-联吡啶- 5,5'-二羧酸的钌-镍金属有机框架用于铁离子的双模电化学发光-荧光检测

研制了一种新型的低毒性Ru-Ni-BPY金属有机骨架（MOF）纳米材料，并在此基础上构建了一种简单灵敏的双模“开-关”铁离子（Fe3+）传感平台。双模检测方法实现了电化学发光（ECL）和荧光（FL）信号的交叉验证，提高了准确性，有效地减少了误差。在0.005 ~ 10 μM和0.078 ~ 10 μM线性范围内，Fe3+能显著猝灭Ru-Ni-BPY MOF的ECL和FL信号，猝灭率分别为91.42%和91.31%，检出限分别为0.1 nM和9.3 nM。该ECL方法不仅实现了大鼠脑微透析液中Fe3+的高效检测，而且成功实现了裸鼠Fe3+的实时FL检测。因此，该平台在环境保护、生命科学、疾病早期诊断等方面具有很大的应用潜力。图形抽象

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.