Eleany Borges-Hernández, Dora Evelia Rodríguez-Felix, Yaniris Garmendía-Diago, José Ramón Flores-León, Teresa del Castillo-Castro, Jesús Manuel Quiroz-Castillo, José Carmelo Encinas-Encinas, Juana Alvarado-Ibarra, Celia Olivia García-Sifuentes
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引用次数: 0
Abstract
The use of biopolymer-based hydrogels represents a promising alternative for achieving controlled drug release. In this study, poly(γ-glutamic acid) hydrogels loaded with neomycin sulfate were obtained. Characterization of drug-loaded hydrogels was conducted using Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FT-IR), and Thermogravimetric Analysis (TGA), confirming the presence of the drug within the polymer matrix and elucidating interactions between neomycin sulfate and polymer chains. The controlled release of neomycin sulfate was evaluated under various pH and temperature conditions. Data fitting the Korsmeyer-Peppas model indicated an “anomalous” diffusion process. Cytotoxicity tests on the L929 cell line revealed biocompatibility at concentrations of 3.125, 6.250, 12.5, and 25 mg/mL. Therefore, this work indicates that poly(γ-glutamic acid)-based hydrogels are biocompatible and highly effective for controlled drug release.
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The Journal of Applied Polymer Science is the largest peer-reviewed publication in polymers, #3 by total citations, and features results with real-world impact on membranes, polysaccharides, and much more.
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