Chemical Sensors and Biosensors for Point-of-Care Testing of Pets: Opportunities for Individualized Diagnostics of Companion Animals

IF 9.1 1区化学 Q1 CHEMISTRY, ANALYTICAL ACS Sensors Pub Date : 2025-04-22 DOI:10.1021/acssensors.4c03664

Wilson Tiago Fonseca, Tatiana Parra Vello, Gabrielle Coelho Lelis, Ana Vitória Ferreira Deleigo, Regina Kiomi Takahira, Diego Stéfani Teodoro Martinez, Rafael Furlan de Oliveira

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Abstract

Point-of-care testing (POCT) is recognized as one of the most disruptive medical technologies for rapid and decentralized diagnostics. Successful commercial examples include portable glucose meters, pregnancy tests, and COVID-19 self-tests. However, compared to advancements in human healthcare, POCT technologies for companion animals (pets) remain significantly underdeveloped. This Review explores the latest advancements in pet POCT and examines the challenges and opportunities in the field for individualized diagnostics of cats and dogs. The most frequent diseases and their respective biomarkers in blood, urine, and saliva are discussed. We examine key strategies for developing the next-generation POCT devices by harnessing the potential of selective (bio)receptors and high-performing transducers such as lateral flow tests and electrochemical (bio)sensors. We also present the most recent research initiatives and the successful commercial pet POCT technologies. We discuss future trends in the field, such the role of biomarker discovery and development of wearable, implantable, and breath sensors. We believe that advancing pet POCT technologies benefits not only animals but also humans and the environment, supporting the One Health approach.

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用于宠物护理点检测的化学传感器和生物传感器：伴侣动物个体化诊断的机遇

即时检测（POCT）被认为是快速和分散诊断的最具颠覆性的医疗技术之一。成功的商业例子包括便携式血糖仪、妊娠测试和COVID-19自检。然而，与人类医疗保健的进步相比，伴侣动物（宠物）的POCT技术仍然明显不发达。本综述探讨了宠物POCT的最新进展，并探讨了猫狗个性化诊断领域的挑战和机遇。讨论了最常见的疾病及其在血液、尿液和唾液中的生物标志物。我们研究了通过利用选择性（生物）受体和高性能传感器（如横向流动测试和电化学（生物）传感器）的潜力来开发下一代POCT设备的关键策略。我们还介绍了最新的研究计划和成功的商业宠物POCT技术。我们讨论了该领域的未来趋势，如生物标志物的发现和可穿戴、植入式和呼吸传感器的发展。我们相信，推进宠物POCT技术不仅有利于动物，也有利于人类和环境，支持“同一个健康”方法。

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来源期刊

ACS Sensors Chemical Engineering-Bioengineering

CiteScore

14.50

自引率

3.40%

发文量

372

期刊介绍： ACS Sensors is a peer-reviewed research journal that focuses on the dissemination of new and original knowledge in the field of sensor science, particularly those that selectively sense chemical or biological species or processes. The journal covers a broad range of topics, including but not limited to biosensors, chemical sensors, gas sensors, intracellular sensors, single molecule sensors, cell chips, and microfluidic devices. It aims to publish articles that address conceptual advances in sensing technology applicable to various types of analytes or application papers that report on the use of existing sensing concepts in new ways or for new analytes.