Acyl-CoA-binding proteins: bridging long-chain acyl-CoA metabolism to gene regulation

Abstract

Acyl-Coenzyme A-binding proteins (ACBPs) sequester and transport long-chain acyl-Coenzyme A (LCA-CoA) molecules, key intermediates in lipid metabolism, membrane biogenesis, and energy production. In addition, recent research emphasizes their regulatory role in linking the metabolic state to gene expression. In animals, ACBPs coordinate acetyl-CoA metabolism and enzyme activity, thereby affecting gene expression through broad signaling networks. In plants, ACBPs contribute to development and stress responses, with hypoxia research showing their involvement in detecting LCA-CoA fluctuations to trigger genetic acclimation. This review explores ACBPs in LCA-CoA signaling and gene regulation, emphasizing their function as universal ‘translators’ of metabolic states for cellular acclimation. Further ACBP research will offer novel regulatory insights into numerous signaling pathways fundamental to health, development, and environmental responses across kingdoms.