Clinical Studies on the Application of Concentrated Growth Factors for Enhancing the Recovery From Flap Ischemia–Reperfusion Injuries

IF 2.5 4区医学 Q2 DERMATOLOGY Journal of Cosmetic Dermatology Pub Date : 2025-04-23 DOI:10.1111/jocd.70203

BoQiao Zhou, XianYan Luo

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Abstract

Objective

To evaluate the therapeutic potential of locally injecting concentrated growth factor (CGF) into flaps for treating flap ischemia–reperfusion injury (FIRI) following reconstructive surgery.

Methods

Nineteen patients with FIRI were enrolled in this study. After clinical identification of ischemia–reperfusion (IR) injury, CGF was prepared from each patient's autologous blood and locally injected into the affected flap tissue. Flap viability was assessed using clinical indicators such as color, texture, and capillary refill. Patients were followed for 6 months postoperatively to assess long-term outcomes.

Results

Seven days after CGF injection, 18 of 19 patients demonstrated complete flap survival. In one case, total necrosis occurred due to hematoma formation and insufficient dressing compression, but healing was achieved through dressing changes. Overall, patients showed improvements in flap color (from dark to ruddy), texture (softened), and skin tension (decreased), with visible wrinkle formation. Long-term follow-up confirmed satisfactory appearance and functional outcomes.

Conclusion

Local injection of CGF effectively enhances flap survival by promoting recovery from IR injury. This strategy may offer a promising adjunctive therapy in reconstructive procedures to improve tissue viability and healing.

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浓缩生长因子促进皮瓣缺血再灌注损伤恢复的临床研究

目的评估向皮瓣局部注射浓缩生长因子（CGF）治疗整形手术后皮瓣缺血再灌注损伤（FIRI）的治疗潜力。方法本研究共纳入 19 例 FIRI 患者。在临床确定缺血再灌注损伤（IR）后，从每位患者的自体血液中制备 CGF，并将其局部注射到受影响的皮瓣组织中。通过颜色、质地和毛细血管再充盈等临床指标来评估皮瓣的存活率。术后对患者进行 6 个月的随访，以评估长期疗效。结果 19 例患者中有 18 例在注射 CGF 七天后皮瓣完全存活。在一个病例中，由于血肿形成和敷料压迫不足导致皮瓣完全坏死，但通过更换敷料后皮瓣得以愈合。总体而言，患者的皮瓣颜色（从深色变为红润）、质地（变软）和皮肤张力（降低）均有所改善，皱纹明显减少。长期随访证实，外观和功能效果令人满意。结论通过促进红外损伤的恢复，局部注射 CGF 能有效提高皮瓣的存活率。这种策略可为重建手术提供一种前景广阔的辅助疗法，以提高组织的存活率和愈合能力。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.