{"title":"A plant dual-kinase protein traps a pathogen effector to trigger immunity","authors":"","doi":"10.1038/s41588-025-02176-4","DOIUrl":null,"url":null,"abstract":"Tandem kinase proteins (TKPs) are key regulators of plant immunity. We found that RWT4, a wheat TKP, confers resistance to the fungal pathogen Magnaporthe oryzae by directly recognizing the effector AvrPWT4. Recognition of AvrPWT4 depends on the RWT4 N-terminal partial kinase duplication region, which is essential for pathogen perception and defense activation.","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"57 5","pages":"1070-1071"},"PeriodicalIF":29.0000,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature genetics","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41588-025-02176-4","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
Tandem kinase proteins (TKPs) are key regulators of plant immunity. We found that RWT4, a wheat TKP, confers resistance to the fungal pathogen Magnaporthe oryzae by directly recognizing the effector AvrPWT4. Recognition of AvrPWT4 depends on the RWT4 N-terminal partial kinase duplication region, which is essential for pathogen perception and defense activation.
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Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation.
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