Effect of Bisphenol A on the neuro-immune-endocrine mechanisms controlling the reproductive axis response during an inflammatory event

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Environmental toxicology and pharmacology Pub Date : 2025-06-01 Epub Date: 2025-04-18 DOI:10.1016/j.etap.2025.104702

Romina Penalba , Juan Manuel Gamez , Nancy Cardoso , Rodrigo M. Bilbao , Osvaldo J. Ponzo , Roxana Reynoso

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Abstract

Endotoxin-induced toxicity could increase with previous exposure to sensitizing agents like endocrine disruptors (EDs). We studied the effects on the reproductive axis on adult male rat pups exposed to BPA since gestation day (GD) 1 to final lactation and its response to LPS before sacrifice. The decrease in GnRH release caused by LPS and BPA was more pronounced in the BPA + LPS group compared to the LPS-only group. While LPS increased nitrate production, the addition of BPA lowered it compared to both the control and LPS groups. A reduction in plasma LH levels was observed in the control, BPA + LPS, and LPS groups. Plasma testosterone decreased in the LPS, BPA, and BPA + LPS groups compared to the control, and in the BPA + LPS group compared to the LPS group. In conclusion, BPA disrupts the reproductive function and sensitizes it to LPS-induced toxicity.

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双酚A对炎症事件中控制生殖轴反应的神经免疫内分泌机制的影响

内毒素引起的毒性可能会随着先前暴露于致敏剂如内分泌干扰物（EDs）而增加。我们研究了BPA对成年雄性大鼠幼仔生殖轴的影响，包括从妊娠第1天（GD）到最终哺乳，以及献祭前对LPS的反应。与仅LPS组相比，BPA + LPS组GnRH释放减少更为明显。虽然脂多糖增加了硝酸盐的产生，但与对照组和脂多糖组相比，BPA的加入降低了硝酸盐的产生。在对照组、BPA + LPS组和LPS组中观察到血浆LH水平降低。血浆睾酮水平在LPS组、BPA组和BPA + LPS组与对照组相比下降，BPA + LPS组与LPS组相比下降。总之，BPA破坏生殖功能，使其对lps诱导的毒性敏感。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.