A comprehensive review of traditional medicinal plants and their role in ovarian cancer treatment

IF 2.7 3区生物学 Q2 PLANT SCIENCES South African Journal of Botany Pub Date : 2025-06-01 Epub Date: 2025-04-28 DOI:10.1016/j.sajb.2025.04.019

Banuppriya Palani , Renu Vajjiravelu , Rajeshkumar Shanmugam , Santhoshkumar Jayakodi

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Abstract

Herbal therapy is a significant and realistic alternative to current medications for treating ovarian cancer. Medicinal plants contain active phytochemicals with promising pharmacological properties that contribute to anticancer activities. Research has shown that botanical extracts and phytonutrients play a crucial role in combating ovarian cancer by promoting apoptosis-inducing enzymatic processes and causing DNA destruction. These secondary metabolites lead to considerable tumor shrinkage in cancerous cellular strains and mouse models. Product research is a valuable strategy for identifying and developing new biologically reactive substances with novel mechanisms of action. The present study aimed to compile a list of plants with anti-ovarian cancer properties for therapeutic applications and provide evidence supporting their effectiveness in tumor treatment. The selected plant species were chosen based on their characteristics and anticancer potential. The findings suggest that medicinal herbs hold promise in treating ovarian carcinoma and warrant further investigation. Future research should focus on optimizing plant extract formulations and conducting in vivo studies and clinical trials to establish their efficacy and safety, potentially transforming ovarian cancer treatment

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传统药用植物及其在卵巢癌治疗中的作用综述

草药疗法是目前治疗卵巢癌的一种重要而现实的替代药物。药用植物含有具有抗癌药理作用的活性植物化学物质。研究表明，植物提取物和植物营养素通过促进诱导细胞凋亡的酶促过程和引起DNA破坏，在对抗卵巢癌中起着至关重要的作用。这些次级代谢物在癌细胞株和小鼠模型中导致相当大的肿瘤缩小。产品研究是识别和开发具有新作用机制的新生物活性物质的有价值的策略。本研究旨在整理具有抗卵巢癌特性的植物清单，并为其治疗肿瘤的有效性提供证据。根据植物的特性和抗癌潜力对所选植物进行筛选。研究结果表明，中药在治疗卵巢癌方面有希望，值得进一步研究。未来的研究应侧重于优化植物提取物配方，并进行体内研究和临床试验，以确定其有效性和安全性，潜在地改变卵巢癌的治疗方法

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来源期刊

South African Journal of Botany 生物-植物科学

CiteScore

5.20

自引率

9.70%

发文量

709

审稿时长

61 days

期刊介绍： The South African Journal of Botany publishes original papers that deal with the classification, biodiversity, morphology, physiology, molecular biology, ecology, biotechnology, ethnobotany and other botanically related aspects of species that are of importance to southern Africa. Manuscripts dealing with significant new findings on other species of the world and general botanical principles will also be considered and are encouraged.