Early membrane lipid changes in laminectomized and traumatized cat spinal cord.

P Demediuk, R D Saunders, D K Anderson, E D Means, L A Horrocks
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引用次数: 29

Abstract

The effects of surgical exposure (laminectomy) and compression trauma on various aspects of membrane lipid metabolism in the feline spinal cord were determined in this study. Tissue samples were frozen in situ and grossly dissected into gray and white portions prior to lipid analyses. Laminectomy alone resulted in measurable changes in spinal cord lipid metabolism, including increases in gray matter free fatty acids, diacylglycerols, and eicosanoids. A 90-min recovery period greatly reduced the levels of these compounds. Compression of the spinal cord with a 170-g weight (following a 90-min recovery period) caused very large increases in gray matter free fatty acids, diacylglycerols, and eicosanoids, and decreases in cholesterol and ethanolamine plasmalogens. Similar, but time delayed changes in these compounds were also observed in white matter.

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层压切除和创伤猫脊髓的早期膜脂变化。
本研究确定了手术暴露(椎板切除术)和压迫性创伤对猫脊髓膜脂代谢各方面的影响。在脂质分析之前,将组织样本就地冷冻并解剖成灰色和白色部分。单纯椎板切除术导致脊髓脂质代谢可测量的变化,包括灰质游离脂肪酸、二酰基甘油和二十烷酸的增加。90分钟的恢复期大大降低了这些化合物的水平。以170克体重压迫脊髓(恢复期90分钟后)导致灰质游离脂肪酸、二酰基甘油和类二十烷酸大量增加,胆固醇和乙醇胺浆磷脂减少。在白质中也观察到类似的,但时间延迟的这些化合物的变化。
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The mechanism of ischemia-induced brain cell injury. The membrane theory. Peroxidative damage to cell membranes following cerebral ischemia. A cause of ischemic brain injury? Phosphoinositide turnover and calcium ion mobilization in receptor activation. Polyamines in cerebral ischemia. Reduction of neural damage in irreversible cerebral ischemia by calcium antagonists.
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