Platelet peroxidase of circulating thrombocytes in acquired refractory anaemias.

S Woessner, R Lafuente, L Florensa
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引用次数: 1

Abstract

The platelet peroxidase (PPO) content of circulating thrombocytes was determined in 10 healthy controls and in 18 cases of acquired refractory anaemia (2 with refractory anaemia, 4 with sideroblastic refractory anaemia, 8 with refractory anaemia with excess of blasts, 3 with refractory anaemia in transformation and 1 with chronic myelomonocytic leukaemia). The thrombocytes of the controls were invariably PPO-positive. No peroxidase deficiency was found in the 4 patients with sideroblastic refractory anaemia. Of the remaining 14 cases PPO-positive and PPO-negative thrombocytes coexisted in 8. Only in 1 case of refractory anaemia with excess of blasts were circulating platelet peroxidase-positive micromegakaryocytes demonstrated. PPO deficiency seems to be an important dysthrombopoietic feature detectable only at an ultrastructural level.

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获得性难治性贫血中循环血小板过氧化物酶的研究。
测定了10例健康对照和18例获得性难治性贫血(2例难治性贫血、4例铁母细胞难治性贫血、8例难治性贫血伴原细胞过多、3例转化性难治性贫血和1例慢性髓单细胞白血病)循环血小板过氧化物酶(PPO)含量。对照组的血栓细胞无一例外地呈ppo阳性。4例铁母细胞性难治性贫血患者均未发现过氧化物酶缺乏。其余14例中有8例血小板呈阳性和阴性。只有1例细胞过多的难治性贫血出现循环血小板过氧化物酶阳性微巨核细胞。多酚氧化酶缺乏似乎是一个重要的血小板生成障碍的特征,只能在超微结构水平检测到。
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