Studies on ethanol and/or nicotine induced acute changes in the levels of plasma amino acids and other biochemical parameters of male Wistar rats.

Alcohol and drug research Pub Date : 1987-01-01
A M Bekairi, F S Abulaban, M Tariq, N S Parmar, A M Ageel
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Abstract

The effects of acute administration of ethanol and nicotine either singly or in combination, have been studied on the plasma amino acids levels and certain biochemical and hematological parameters in the rats. Both ethanol and its combination with nicotine produced significant reduction in the levels of a number of amino acids and the total amino acid pool. Only the levels of taurine and hydroxyproline were increased in the ethanol treated rats, whereas its combination with nicotine resulted in markedly elevated levels of hydroxyproline, ornithine and taurine. These changes were also accompanied by a significant rise in blood glucose, ALT, AST, blood urea and uric acid and a significant reduction in the total protein and triglycerides levels. Nicotine by itself produced less profound effect on the plasma amino acids and other biochemical parameters.

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研究乙醇和/或尼古丁对雄性Wistar大鼠血浆氨基酸水平和其他生化参数的急性变化。
研究了乙醇和烟碱急性单独或联合给药对大鼠血浆氨基酸水平和某些生化及血液学指标的影响。乙醇及其与尼古丁的组合均显著降低了一些氨基酸和总氨基酸库的水平。在乙醇处理的大鼠中,只有牛磺酸和羟脯氨酸的水平增加,而与尼古丁联合使用则导致羟脯氨酸、鸟氨酸和牛磺酸的水平显著升高。这些变化还伴随着血糖、ALT、AST、血尿素和尿酸的显著升高,以及总蛋白和甘油三酯水平的显著降低。尼古丁本身对血浆氨基酸和其他生化参数的影响较小。
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