{"title":"Development of tolerance to ethanol-induced tachycardia in rats.","authors":"L A Pohorecky, J T Peterson, J A Carpenter","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Development of tolerance to ethanol was examined using heart rate as a measure. Ethanol-treated rats were infused IG with 8-11 g/kg/day (in 3 divided doses), control rats received similar infusions of either equicaloric dextrin-maltose or water (equivolumetric) for a period of 17 days. On days 1, 5, 9, 13 and 17 of treatment heart rate was recorded before and at 10, 20 and 30 minutes after injection of a challenge dose of 2 g/kg ethanol, dextrin-maltose or water. The tachycardia produced by ethanol increased with days of chronic treatment to a maximum on the 9th day of treatment. Significant tolerance to the tachycardia was evident only on the 17th day of treatment. Neither control showed significant changes in heart rate.</p>","PeriodicalId":7671,"journal":{"name":"Alcohol and drug research","volume":"6 6","pages":"431-9"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alcohol and drug research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Development of tolerance to ethanol was examined using heart rate as a measure. Ethanol-treated rats were infused IG with 8-11 g/kg/day (in 3 divided doses), control rats received similar infusions of either equicaloric dextrin-maltose or water (equivolumetric) for a period of 17 days. On days 1, 5, 9, 13 and 17 of treatment heart rate was recorded before and at 10, 20 and 30 minutes after injection of a challenge dose of 2 g/kg ethanol, dextrin-maltose or water. The tachycardia produced by ethanol increased with days of chronic treatment to a maximum on the 9th day of treatment. Significant tolerance to the tachycardia was evident only on the 17th day of treatment. Neither control showed significant changes in heart rate.
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