Infectious foci in chronic osteomyelitis of the jaws

Karin Wannfors , Lars Hammarström
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引用次数: 26

Abstract

Chronic osteomyelitis of the jaws has a varied clinical appearance and an unclear etiology. In a retrospective study based on case histories and histological material from 24 patients with chronic osteomyelitis, no specific correlation could be found between clinical symptoms and morphological changes in bone. In 10 patients, bacteria were found in certain foci such as osteocytic lacunae of necrotic bone and dentinal tubules of embedded tooth fragments. In these foci, the bacteria probably escaped the immunological response as well as the antibiotic tretment. From these foci, the bacteria might maintain an inflammatory reaction in the surrounding bone. In some patients, the mandibular canal seemed to be a pathway for the spreading of the inflammatory process.

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慢性颌骨骨髓炎的感染性病灶
颌骨慢性骨髓炎临床表现多样,病因不明。在一项基于24例慢性骨髓炎患者的病例史和组织学资料的回顾性研究中,没有发现临床症状与骨形态学改变之间的特定相关性。10例患者在坏死骨的骨细胞腔隙和嵌埋牙碎片的牙本质小管等部位发现细菌。在这些病灶中,细菌可能逃脱了免疫反应和抗生素治疗。从这些病灶,细菌可能在周围的骨头中维持炎症反应。在一些患者中,下颌管似乎是炎症过程扩散的途径。
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