[Investigations on the configuration of 4-nitro imidazole nucleosides].

Abstract

It is demonstrated that the 220—225 nm Cotton effect of 4-nitro imidazole nucleosides can be used for the determination of the configuration of this class of compounds. A more detailed picture about conformation and configuration of the sugar residue is received from the copperammonia complexes of these nucleosides. The pH-dependency of the stability and the complex ratio are discussed for a furanose moiety. Correlation between signs and intensities of the Cotton effects and configurations and conformations of the diol structures are discussed.