Difunctional molecularly imprinted polymers and heterostructured CdS nanoparticle-sensitized ZnO nanorod arrays for antibody-free photoelectrochemical alpha-fetoprotein sensor

IF 4.5 3区 化学 Q1 Chemical Engineering Journal of Electroanalytical Chemistry Pub Date : 2023-09-01 DOI:10.1016/j.jelechem.2023.117631
Yang Zang, Yan Zhang, Ruhua Wei, Huaiguo Xue, Jingjing Jiang
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Abstract

An antibody-free molecularly imprinted photoelectrochemical sensor was developed for alpha-fetoprotein (AFP) detection by means of difunctional polydopamine-based molecular imprinting polymers (PDA-MIP) on CdS nanoparticle-decorated ZnO nanorod arrays (CdS@ZnO NAs). Among them, the heterostructured CdS@ZnO NAs could accelerate the spatial separation of electron-hole pairs; while PDA-MIP not only provided abundant target recognition sites without expensive antibody, but also further increase the systemic photocurrent due to the enhanced light absorption capacity. After removing template molecules from PDA-MIP, the resulting imprinted cavities could be occupied by target AFP, leading to a decreased photocurrent. Moreover, the prepared sensor had a wide linearity in the range from 1 pg mL−1 to 1000 ng mL−1 with a low detection limit of 0.38 pg mL−1, as well as excellent selectivity and good stability. The application of AFP analysis in real human serum was also achieved, and the recoveries ranged from 99.2% to 105.2%.

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双功能分子印迹聚合物和异质结构CdS纳米颗粒敏化ZnO纳米棒阵列用于无抗体的光电化学甲胎蛋白传感器
利用双功能聚多巴胺分子印迹聚合物(PDA-MIP)在纳米粒子修饰的ZnO纳米棒阵列(CdS@ZnO NAs)上制备了一种检测甲胎蛋白(AFP)的无抗体分子印迹电化学传感器。其中,异质结构CdS@ZnO NAs能够加速电子-空穴对的空间分离;而PDA-MIP不仅在没有昂贵抗体的情况下提供了丰富的目标识别位点,而且由于光吸收能力的增强,进一步增加了系统光电流。从PDA-MIP中去除模板分子后,得到的印迹腔可以被靶AFP占据,导致光电流降低。该传感器在1 pg mL−1 ~ 1000 ng mL−1范围内具有较宽的线性,检测限为0.38 pg mL−1,具有良好的选择性和稳定性。在人血清中也实现了AFP分析的应用,回收率为99.2% ~ 105.2%。
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来源期刊
Journal of Electroanalytical Chemistry
Journal of Electroanalytical Chemistry Chemical Engineering-General Chemical Engineering
CiteScore
7.50
自引率
6.70%
发文量
912
审稿时长
>12 weeks
期刊介绍: The Journal of Electroanalytical Chemistry is the foremost international journal devoted to the interdisciplinary subject of electrochemistry in all its aspects, theoretical as well as applied. Electrochemistry is a wide ranging area that is in a state of continuous evolution. Rather than compiling a long list of topics covered by the Journal, the editors would like to draw particular attention to the key issues of novelty, topicality and quality. Papers should present new and interesting electrochemical science in a way that is accessible to the reader. The presentation and discussion should be at a level that is consistent with the international status of the Journal. Reports describing the application of well-established techniques to problems that are essentially technical will not be accepted. Similarly, papers that report observations but fail to provide adequate interpretation will be rejected by the Editors. Papers dealing with technical electrochemistry should be submitted to other specialist journals unless the authors can show that their work provides substantially new insights into electrochemical processes.
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