Engineering antimicrobial surfaces by harnessing polymeric nanoassemblies

IF 7.9 2区 化学 Q1 CHEMISTRY, PHYSICAL Current Opinion in Colloid & Interface Science Pub Date : 2023-08-01 DOI:10.1016/j.cocis.2023.101706
Djallal Ikkene , Olivia M. Eggenberger , Cora-Ann Schoenenberger , Cornelia G. Palivan
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引用次数: 1

Abstract

The increasing number of multidrug-resistant bacteria is a growing threat to global public health. Contaminated surfaces pose a major problem in the spreading of these superbugs and are a source of bacterial infections that are difficult to treat. Surfaces that repel bacteria or impede biofilms where bacteria are inaccessible to conventional drugs are in great demand for medical and technological applications. Immense multi-disciplinary efforts are being made to develop biocompatible, long-lasting, scalable, and cost-effective antimicrobial surfaces. Here, we highlight emerging strategies that involve harnessing natural and synthetic polymeric nanoassemblies that are antimicrobial either by themselves or through association with antimicrobial compounds to engineer antimicrobial surfaces. Our aim is to move underexplored nanoassemblies into the limelight. Based on their chemical versatility, structural tenability, and orthogonal activity of associated molecules and structures, the nanoassemblies discussed overcome cytotoxicity, non-biodegradability, and short-term antibacterial activity to offer novel surfaces with improved antibacterial and antibiofilm prospects.

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工程抗菌表面利用高分子纳米组件
越来越多的耐多药细菌对全球公共卫生构成越来越大的威胁。受污染的表面是这些超级细菌传播的主要问题,也是难以治疗的细菌感染的来源。在医学和技术应用方面,传统药物无法接近细菌的表面排斥细菌或阻碍生物膜的需求很大。巨大的多学科的努力正在开发生物相容性,持久,可扩展和具有成本效益的抗菌表面。在这里,我们强调了新兴的策略,包括利用天然和合成的聚合物纳米组件,这些纳米组件本身具有抗菌性,或者通过与抗菌化合物结合来设计抗菌表面。我们的目标是将未被充分探索的纳米组件推向聚光灯下。基于其化学通用性、结构可持续性以及相关分子和结构的正交活性,所讨论的纳米组件克服了细胞毒性、不可生物降解性和短期抗菌活性,提供了具有改善抗菌和抗生物膜前景的新型表面。
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来源期刊
CiteScore
16.50
自引率
1.10%
发文量
74
审稿时长
11.3 weeks
期刊介绍: Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications. Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments. Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.
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