Basal and stimulated levels of prolactin, TSH and LH in serum of chronic schizophrenic patients, long-term treated with neuroleptics.

D Naber, M Ackenheil, G Laakman, H Fischer, K von Werder
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引用次数: 25

Abstract

Basal and stimulated (0.2 mg TRH, 0.025 mg LHRH) levels of prolactin, TSH and LH were measured in serum of 12 male and 10 female chronic schizophrenic patients, hospitalized and treated with neuroleptics from 6-21 years. The mean values of the 3 pituitary hormones were within the normal range in both sexes. Tolerance to the prolactin increasing effect of neuroleptics appears to develop after long-term neuroleptic treatment. TSH and LH secretion are not markedly impaired by chronic neuroleptic treatment.

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长期服用抗精神病药的慢性精神分裂症患者血清泌乳素、促甲状腺激素和LH的基础和刺激水平。
本文测定了6 ~ 21岁住院并服用抗精神病药物治疗的12例慢性精神分裂症患者血清泌乳素、TSH和LH的基础水平和刺激水平(0.2 mg TRH, 0.025 mg LHRH)。3种垂体激素的平均值均在正常范围内。对抗精神病药催乳素增加作用的耐受性似乎是在长期抗精神病药治疗后产生的。慢性抗精神病药物治疗对TSH和LH的分泌没有明显的影响。
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