The pathogenetic connection between Graves' disease and chronic lymphocytic thyroiditis. (The role and incidence of thyroid stimulating antibodies).

Acta medica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

A Leövey, G Bakó, I Sztojka, L Bordán, T Szabó, K Kálmán, C Balázs

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Abstract

Antibody-positivity to thyroid specific antigens (Htg, microsomal) and/or lymphocytic infiltration of the gland's parenchyma were observed in 207 (55%) of 377 patients with Graves's disease. Only in 48 (12.7%) of the cases were the findings in agreement with the criteria of chronic lymphocytic thyroiditis. Human thyroid stimulating antibody (HTSab) was detected in 135 (65%) of these 207 patients. In cases of Graves' disease associated with chronic lymphocytic thyroiditis, this proportion was found to be as high as 89.6% and attained even 100% in cases of Hashitoxicosis (39 patients). The presence of HTSab thus seems to form one of the features of patients with Hashitoxicosis. Infiltrative ophthalmopathy also showed a remarkably high incidence (59%) in this porcess. The typical prevalence of Graves' disease in females in the present material attained a 15:1 female-to-male ratio when the disease was associated with chronic lymphocytic thyroiditis. The results of the present study suggest that chronic lymphocytic thyroiditis associated with Graves' disease promotes the formation of thyroid stimulating antibodies.

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Graves病与慢性淋巴细胞性甲状腺炎的发病关系。(促甲状腺抗体的作用和发生率)。

377例Graves病患者中有207例(55%)甲状腺特异性抗原(Htg、微粒体)抗体阳性和/或腺实质淋巴细胞浸润。只有48例(12.7%)符合慢性淋巴细胞性甲状腺炎的诊断标准。在这207例患者中，135例(65%)检测到人促甲状腺抗体(HTSab)。在Graves病合并慢性淋巴细胞性甲状腺炎的病例中，这一比例高达89.6%，在39例Hashitoxicosis病例中甚至达到100%。因此HTSab的存在似乎形成了hashit中毒患者的特征之一。在此过程中浸润性眼病的发生率也非常高(59%)。在目前的材料中，Graves病在女性中的典型患病率达到15:1的男女比例，当该病与慢性淋巴细胞性甲状腺炎相关时。本研究结果提示慢性淋巴细胞性甲状腺炎与Graves病相关，可促进甲状腺刺激抗体的形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acta medica Academiae Scientiarum Hungaricae

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